A synthesis of 3,3-diarylazetidines
from N-Boc-3-aryl-3-azetidinols
using Friedel–Crafts arylation conditions with AlCl3 is described. A series of substituted diarylazetidines were readily
prepared and isolated as the oxalate salts in high yield and high
purity. The 3,3-diarylazetidine oxalates were then easily converted
into N-alkyl and N-acyl analogues
(RX, NaHCO3/DMF/100 °C) in high overall yields.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.