No abstract

1.3. Results: SVR12 rate was 95.5%. Decompensation was observed in 39 (5.8%) patients, death in 11 (1.6%). Variables significantly associated with decompensation or deaths were similar: cirrhosis stage, bilirubin, prothrombin activity, MELD or Child-Pugh scores. ROC curve analysis showed that MELD score ≥10 (HR 5.1, 95% CI, 1.9-13.6) and Child-Pugh score ≥7 (HR 4.6, 95% CI, 2.1-10.1) were predictive of decompensation and/or death. Conclusion:DAAs were effective and safe in patients with compensated cirrhosis but further studies in decompensated cirrhosis are needed to better delineate the MELD and/or Child-Pugh scores that ensure a good safety profile or being appropriate for indicating liver transplant instead of antiviral therapy.