Overall, our study demonstrates that ADSCs treatment significantly enhances skin flap survival in the aftermath of ischemia to an extent that almost equals surgical results without ischemia. This effect is accompanied with a pronounced and significant angiogenic response and an improved blood perfusion.

BackgroundChildren with haematological or autoimmune diseases (e.g. lupus erythematodes) are prone to acquire avascular osteonecrosis (AVN) following treatment with high dose steroids. More than 35% of those with advanced AVN stages (Marcus/Enneking II and III) fail to respond solely to core decompression.Multipotent mesenchymal stromal cells (MSC) are capable of transforming into various mesenchymal tissues, e.g. bone. A combination therapy might be of benefit for those children.

No abstract