Background Medication-related osteonecrosis of the jaw (MRONJ) is a complication affecting patients who are being treated with antiresorptive or antiangiogenic medication. These patients require meticulous treatment planning and management strategies. This research aimed to assess the knowledge of dental practitioners and students in their professional years regarding MRONJ. Methods A cross-sectional study was conducted among 345 dental practitioners and students in their professional years of both genders, in governmental and private dental schools. The data was collected using an electronic and paper-based self-administered structured questionnaire with six sections. The data was entered and analyzed using SPSS Version 23, and a P-value <0.05 was considered significant. A Chi-square test was used to compare the categorical variables. Results Though more than half of the sample 68% received information about antiresorptive and antiangiogenic drugs during their studies, the level of knowledge was low. The primary diseases targeted by antiresorptive and antiangiogenic medications were not known by the majority of the sample. Almost half of the sample could not identify any antiresorptive or antiangiogenic medication and only 28.1% knew the correct definition of MRONJ. Conclusion The level of knowledge regarding MRONJ is a concern, necessitating more educational courses and workshops.

The objective of this study is to evaluate the effectiveness of discontinuing high-dose antiresorptive (AR) therapy in reducing the risk of medication-related osteonecrosis of the jaw (MRONJ) in patients treated with AR medications and undergoing dentoalveolar surgery or tooth extractions.The review was carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. A literature search was conducted using the databases MEDLINE, Embase, Web of Science, Scopus, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception till the 1st of April, 2022. Both observational and interventional studies that evaluated the effect of AR drug holiday in the development of MRONJ in patients receiving AR medications and who require dentoalveolar surgical procedures were included. Trials published as abstracts, case reports, case series, non-systematic reviews, and others were excluded. All findings were reported as odds ratios (ORs) and corresponding 95% confidence intervals (CIs). The Newcastle-Ottawa Quality Assessment Scale was used to evaluate the methodological quality assessment, and the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach was used to evaluate the quality of the evidence.Eight articles (6808 subjects) were included for analysis. Of the participants, 4847 cases (drug holiday group) were compared to 1961 controls (non-drug holiday group). Based on the random effects model, the pooled summary OR was 0.73 (95% CI: 0.51-1.06) for the drug holiday group compared to the non-drug holiday group. In other words, the drug holiday group was not significantly different from the non-drug holiday group in the development of MRONJ following a tooth extraction procedure (p = 0.10). The statistical heterogeneity was low across all studies (I 2 = 13%, p = 0.33).Within the limits of the available evidence, our findings revealed that drug holidays with AR will not minimize the risk of MRONJ and thus cannot be advised. It may be possible to arrive at more definitive conclusions from large prospective studies and randomized trials of good quality.

Aim: The aim of this study was to evaluate radiation exposure in dental open clinics in King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS) using thermoluminescence dosimeters (TLDs) to check if it exceeds the annual assigned exposure limit and to assess students' practices regarding radiation protection measures and their knowledge regarding the application of digital remote-control settings and TLDs. Materials and Methods: This pilot institutional-based observational study was conducted among the clinical year students and interns at KSAU-HS College of Dentistry open clinical areas using TLDs and questionnaires. Sixteen lithium fluoride TLDs (TLD-100) were distributed evenly in the clinical areas occupied by clinical year dental students and interns for 24 working days from September 15 to October 20, 2019. Each TLD was labeled with a serial number and fixed at the assigned clinic of each specialty. The TLDs were placed in a zigzag manner at the right corner of the selected clinic to prevent overlapping of the area coverage by each dosimeter. Results: The mean monthly TLD readings were found to be 69.265 uSv with a higher mean value in the female clinical area (74.2975 uSv) than the male clinical area (64.234 uSv). Taking into account the 8 months of clinical exposure during the academic year, the expected annual radiation exposure would be 0.554 mSv which is significantly lower than the annual limit of radiation exposure recommended by the International Commission on Radiological Protection, i.e., 1 mSv. Conclusion: TLD readings concluded that radiation exposure was within safe limits with an estimation of 0.544 mSv per year. However, students require further education regarding protective and safety measures and the utilization of radiation equipment. Clinical Significance: The lack of studies regarding the amount of radiation exposure from dental imaging and the safety of intraoral radiographic machines present in open clinics in any educational institute necessitates conducting this kind of study.