FGA users were at a higher risk of hip fracture than SGA users. Both FGAs and SGAs were associated with an increased risk of fractures, especially among the older population. Therefore, the benefit of the off-label use of antipsychotics in elderly patients should be weighed against any risks for fracture.

The available evidence suggests use of with first-generation antipsychotics as opposed to second-generation antipsychotics significantly increased the risk of CVA.

In cancer patients, FDX is effective treatment for the first episode of CDI after failure of standard therapies and treatment of recurrent CDI. This was interesting given the large number of high-risk patients who continued to receive concomitant antimicrobial therapy, which is common in this immunocompromised patient population.

were conducted in South America (92%), particularly in Brazil (64%). The mean age was 60 ± 9 years and the mean ejection fraction was 36 ± 9%. Most studies evaluated more than one etiology (79%) but the etiology more studies exclusively was Chagas disease (13%). The incidence of HF ranged from 199 to 557 cases per 100,000 person-years and the pooled prevalence was 1%, being higher in older populations. Hospitalization rates in patients with HF ranged from 28 to 31% at different time points, and the median length of stay was 7.0 days. In-hospital mortality was 11.7%, being higher in patients with worse ejection fraction, with ischemic and with Chagas disease. Mortality at one year was 24.52% (95%CI 19.42 to 30.02). ConClusions: This SR of HF in Latin America, could help decision-makers to design better preventive strategies, and guide effective patient-centered care.

to 11%-16% of ezetimibe users, and 11%-19% of fibrate users. Nearly 4% of statin users augmented their regimen during the year, compared with 56%-61% of ezetimibe and 38%-51% of fibrate users. The proportion of patients not meeting the LDL-C target was 71% and 69% in the CV High Risk and CV Event History cohorts at index, respectively, and 65% for both at 12 months. Approximately 60% of diabetic patients of CV High Risk cohort did not meet LDL-C target at both index and 12 months. ConClusions: Adherence to LMT after CV events was best for statins. Patients receiving fibrates or ezetimibe had higher rates of switching or augmentation. LDL-C goal attainment is low, representing a substantial unmet medical need.