Introduction: Jawbones can be affected by many lesions due to conditions such as genetic, metabolic, inflammatory, cystic, and tumoral. For proper diagnosis and treatment, dentists should be aware of the most prevalent types of lesions, demographic and clinical features, and their distribution patterns within the population. The present study aimed to evaluate the distribution pattern of jaw bone lesions during 7 years in Esfahan. Materials & Methods: This retrospective analytic descriptive study was performed on 370 reports available at the department of oral pathology at Isfahan Azad university. Demographic data, clinical features, and histopathology diagnosis were gathered and analyzed statistically using ANOVA and Chi-Square (α = 0.05). Results: Intraosseous lesions consisted 28.6% of all lesions, 41.5% in females and 58.4% in males (p value < 0.05. (Mean age of male patients was 35.96 and 33.70 for females (p value > 0.05). Lesions were mostly in the right lower jaw (p value < 0.05). The swelling was the only clinical feature reported in only 15%. Of 106 intraosseous lesions, 73 cases were odontogenic cysts, 19 inflammatory,9 odontogenic tumors,2 benign non-odontogenic tumors, and 3 non-odontogenic cysts. The periapical and dentigerous cyst was the most prevalent lesions reported. Conclusion: Results of the present study showed jaw bone lesions mostly occurred in the right lower jaw in male patients. The difference in the distribution of the lesions in comparison to similar studies in this context can be attributed to the difference in geographical region necessitating further studies.