Background:Fatigue is taken into account as one of the most important factors affecting quality of life in patients with multiple sclerosis. Such patients can certainly control levels of fatigue, increase their abilities to perform daily activities, and show adaptive behaviors if they are aware of non -pharmacological approaches to reduce fatigue. Thus, the purpose of the present study was to determine the effect of motivational interviewing on fatigue among patients affected by multiple sclerosis in the city of Ilam, Iran. Methods: In the present quasi -experimental study, a total number of 60 patients with multiple sclerosis referring to Shahid Mostafa Khomeini Teaching Hospital in the city of Ilam were randomly allocated to two experimental (intervention) (32 patients) and control (28 patients) groups. To collect the data, the fatigue impact scale (FIS) was used. The experimental (intervention) group also received motivational interviewing based on Miller and Rollnick's Model. To this end, the given patients were divided to seven groups of five individuals and the motivational interviews were conducted lasting between 45 to 60 minutes during five sessions and on a weekly basis for each group. The questionnaires were also completed prior to the intervention and four weeks after the final training session by patients in the experimental (intervention) and control groups. To analyze the data, descriptive and inferential statistics were employed and significance level of less than 0.05 was considered. Results: The findings of this study showed that there was no difference between fatigue before and after the intervention in the experimental (66.32 (10.87)) and control (63.28 (8.29)) groups. However, after the intervention, the fatigue of the experimental (41.75 (14.35)) patients was reduced compared to that of control (62.13 (7.69)) and pre -intervention patients. Conclusions:The findings of the present study showed that implementation of motivational interviewing could alleviate fatigue among patients with multiple sclerosis; therefore, nurses were recommended to give daily care to these patients using this type of interview and to provide the basis for promoting health status of such patients.

Introduction: Cisplatin is a strong anticancer medicine, but its use is limited due to the potential nephrotoxicity induction. Objectives: The present study seeks to determine the impact of Hypericum hydroalcoholic extract on cisplatin-induced nephrotoxicity. Materials and Methods: Thirty-two male rats were assigned to groups 1 to 4. Group 1, control (Cont); treated by saline (IP). Group 2, Cis; cisplatin [intraperitoneal (IP), 7.5 mg/kg]. Group 3, CisH; cisplatin + Hypericum (70 mg/kg, IP, for one week). Group 4, HCis; first treated with Hypericum for a week, followed by cisplatin. Renal tissue and blood samples were obtained a week after cisplatin injection for tissue assay and biochemical analysis. Kidney tissue damage score (KTDS), plasma creatinine (Cr), blood urea nitrogen (BUN), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) were measured. Results: Kidney weight showed significant differences between the treated groups and the Cont group (P<0.001). Serum BUN, Cr, SGOT, and SGPT increased significantly in Cont (P<0.01). BUN decreased in CisH and HCis groups compared to Cis group, although there was no significant difference. Serum Cr, SGOT, and SGPT decreased significantly in CisH and HCis groups compared to the Cis group (P<0.05). MDA and KTDS increased in the Cis group and decreased significantly in the CisH and HCis groups compared to the Cis group (P<0.05). Serum SOD and CAT decreased significantly in Cis compared to Cont (P<0.05) and increased in CisH and HCis groups compared to Cis. There was no significant difference between the CisH and HCis groups in any of the measured parameters. Conclusion: This study reveals that pretreatment with Hypericum extract or its concomitant administration with cisplatin can moderate the side-effects of cisplatin, improve renal function and decrease lipid peroxidation, renal toxicity and the KTDS.

Advances and developments in medical science have greatly extended the scope of medical interventions in recent decades, which has raised numerous ethical challenges in this domain. Therefore, the present study investigated levels of awareness of a patient's bill of rights and its observance in 2015 in hospitals in the city of Ilam in Iran among patients with heart disease. In this cross-sectional descriptive study, 200 patients with heart problems admitted to hospitals in Ilam were recruited using the convenience sampling method. The research instrument was a three-part questionnaire about a patient's bill of rights completed using the interview method. The data were analyzed via SPSS Version 21 with respect to descriptive statistics (means and standard deviations), inferential tests (Pearson's correlations), and interpreted at a statistical signifi cance cutoff of 0.05. Analysis of awareness of a patient's bill of rights revealed that 38% (76) had poor awareness, 59.5% (119) had moderate awareness, and fi ve participants (5%) had good awareness. Regarding observance of a patient's bill of rights, 22% (44) had a poor level of awareness, 34.5% (69) reported moderate awareness, and 43.5% (69) had high awareness. Moreover, no statistically signifi cant difference was found between the level of awareness of a patient's bill of rights and its observance. Only a small number of patients had good levels of awareness of a patient's bill of rights. Thus, healthcare policymakers must take the necessary steps regarding patients' awareness of a patient's bill of rights.