Background: Epidural analgesic technique is the most commonly used and most effective analgesia during labor. Intrathecal labor analgesia is alternatively and effective method to provide labor analgesia. Aim of Study: To compare the effect of epidural bupivacaine versus single-dose intrathecal bupivacaine during labor of multiparous women on the duration of labor analgesia, progress of labor, block characteristics and side effects. Material and Methods: In a prospective randomized double-blind study, 80 multiparous women of ASA class I and II were randomly allocated into two groups of pregnant women 40 each. The spinal group received hyperbaric bupivacaine 0.5% at a dose of 3.75mg (0.75ml) of hyperbaric bupivacaine with 25ug fentanyl (0.5ml) and diluted with sterilized normal saline to 1.5ml whereas the epidural group received isobaric bupivacaine 8-10ml of 0.125% bupivacaine with fentanyl 50µ g. Patients were monitored for hemodynamics, sensory and motor block characteristics, side effects, duration of stages of labor and pain intensity was also recorded on a visual analogue scale. Results: Maternal hemodynamics showed a nonsignificant changes between both groups. Onset of sensory block and duration were significantly delayed in epidural group in comparison to spinal group (8.80±5.27, 163±16.64min) vs (4.6± 1.20, 120.2±3.33min) and visual analogue scale comparable in both groups but scale was lower in the spinal group. Patient's satisfaction was insignificantly more in S group. The duration of the first and second stages of labor in the spinal group was shorter than that in the epidural group and incidence of maternal complications in both groups were insignificant. Conclusion: A safe and effective alternative method to epidural analgesia is a single-dose intrathecal bupivacaine.