Introduction: Antioxidant and hypoglycemic properties of some plant seeds are considered natural preventives for diabetic-associated glycation. This study is concerned with the evaluation of the bioactive components of black chia and garden cress seeds and the examination of their modulatory effects on hyperglycemia and associated glycation induced by streptozotocin (STZ) injection. Methods: Forty male rats were divided into 4 groups, 10 rats each: Group 1 (healthy control group); group 2 (diabetic group): rats injected STZ intraperitoneally to induce hyperglycemia; group 3 and group 4: rats treated (after diabetic induction) with 1 mL (20% w/w) black chia and garden cress seed extract, respectively. Results: STZ injection caused marked hyperglycemia, oxidative stress, glycation, and inflammation condition with disturbance in organs functions and structural alterations in pancreatic tissue, while; treatment with black chia and garden cress seed extracts showed remarkable (P < 0.05) modulatory effects on hyperglycemia and associated disorders. Conclusion: Black chia and garden cress seeds might be used in the management of diabetes and associated glycation.

Ulcerative colitis (UC) is one common type of inflammatory bowel disease characterized by prolonged inflammatory conditions. Plant oils are thought to offer an alternative to pharmaceutical medications for diseases such as UC. This study aimed to investigate the curative effects of flaxseed and psyllium seed oils on the UC model induced by 70% ethanol intrarectal injection (0.5 mL/100g body weight). Animals were separated into 4 groups; the control group received saline and the experimental groups received (500 mg kg -1 b.wt.) of flaxseed and psyllium seed oils. Therapeutic effects were determined by measuring hematological parameters; (Red blood cells (RBCs), white blood cells (WBCs) (total and differential) and platelets counts, hemoglobin (Hb) concentration, hematocrit (packed cells volume) PCV, erythrocytes indices), colonic oxidative stress parameters; malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT) and myeloperoxidase (MPO), as well as the colonic inflammatory parameters; interleukin-1β (IL-1β), interleukin-10 (IL-10), prostaglandin I2 (PGI2) and leukotriene B4 (LTB4) in addition to, histological examinations of colon tissues. The results of the current investigation demonstrated the antiulcer properties of tested oils; FSO and PSO. Tested oils improved oxidative stress and inflammatory indicators in colon tissues, hematological parameters, and modified colon structural and histological changes. Oils from psyllium and flaxseed may be utilized to treat acute UC induced by alcohol.

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