Objectives:To determine patterns of physical activity (PA) along domains of work-transport-leisure among adult Saudis, sociodemographic correlates of PA and perceived personal barriers to leisure-time-related physical inactivity in Al-Hassa, KSA.Methods:A cross-sectional study in which 2176 adult Saudis attending urban and rural Primary Health centers were selected using multistage proportionate sampling method. Participants were personally interviewed to gather information regarding sociodemographics, PA pattern using Global Physical Activity Questionnaire (GPAQ), and perceived barriers toward recreation-related PA. Analysis was carried out along GPAQ protocol.Results:Median total physical activity was 2304 METs-minutes/week. Fifty-two percent of subjects were sufficiently active meeting the minimum recommendations when considering total PA and 21% of the subjects were sufficiently active in leisure-time-related activity with ≥ 5 days of any combination of walking, moderate or vigorous-intensity activities with a total of at least 600 METs-minutes/ week. Regression analyses showed that females, higher educational and occupational status were negative predictors to total and leisure-related PA. Barriers perceived toward leisure-related PA included weather, traditions, lack of facilities and time.Conclusion:A low PA pattern along the 3 domains of PA may impose a refection toward more sedentary life style in Saudi Arabia.

Chronic disease(s) can significantly reduce work productivity by increasing absenteeism, presenteeism, and net negative critical incidents.

Chronic hepatitis C virus (HCV) viremia has been known to provoke a plethora of autoimmune syndromes referred to as extrahepatic manifestations of chronic HCV infection. Aim of the current study was to assess the prevalence of rheumatologic manifestations among Egyptians with hepatitis C infection and its' association with cryoglobulin profile. The current research represents a cross-sectional study where patients with chronic HCV infection attending the outpatient clinic of the National Hepatology and Tropical Medicine Research Institute over a period of 1 year were interviewed. Patients with decompensated liver disease, on interferon therapy, having end-stage renal disease or coexisting viral infection like hepatitis B surface antibody positive patients were all excluded from the research. Laboratory investigations as well as serological assay including cryoglobulin profile, rheumatoid factor, antinuclear antibody, HCV-PCR were performed. Three hundred and six patients having chronic HCV infection were interviewed in this research. The overall estimated prevalence of rheumatologic manifestations in the current research was 16.39%, chronic fatigue syndrome 9.5%, sicca symptoms 8.8%, arthralgia 6.5%, fibromyalgia 1.9%, myalgia 1.3%, arthritis 0.7%, cryoglobulinemic vasculitis 0.7%, autoimmune hemolytic anemia 0.7%, thrombocytopenia 0.7%. Xerophthalmia was significantly present in male population (p = 0.04), whereas fibromyalgia, cryoglobulinemic vasculitis, arthritis, and autoimmune hemolytic anemia were significantly present in female population under study (p < 0.05). In chronic HCV genotype 4 infection, the prevalence of rheumatologic manifestations was 16.3% with chronic fatigue syndrome and sicca symptoms being the most common with no significant correlation to the degree of elevation of liver disease or viral load.

Background: Hepatitis C virus (HCV) is a known risk factor for hepatocellular carcinoma. Several epidemiological studies have pointed out to an association of HCV infection with other extrahepatic malignancies. The role of chronic HCV in breast cancer causation is less clear. Egypt is an endemic area of HCV infection with resulting significant morbidity. The association between HCV status and breast cancer risk in Egyptian women is hitherto unknown. Methods: A retrospective study was performed. The prevalence of anti-HCV seropositivity was estimated in a sample of women with a breast cancer diagnosis, retrieved from the hospital records, and was compared to the raw data of a population study in Egypt. Anti-HCV negative and positive patients were compared regarding the disease course and outcome. Results: Retrospective analysis revealed a markedly high prevalence of anti-HCV seropositivity in young breast cancer patients. In patients younger than 45 years, 13.4% were anti-HCV positive. Seropositivity was 6-fold higher in these patients than in adult females of the same age without cancer diagnosis ( P = .003). The biological type, tumor size, nodal status, and disease-free survival were not affected by the patients’ HCV status. Conclusion: Young Egyptian breast cancer patients have a dramatically high prevalence of HCV seropositivity. Further population studies are strongly required to investigate the epidemiological association of these two significant health problems.

The 150 mg dose of canakinumab prevented recurrence of gout flares with a relative risk reduction compared with TA of 94% at 8-weeks post-dose and was well tolerated.