Background Colorectal cancer (CRC) is the third most frequent kind of cancer globally, making it a significant public health problem. This project aims to construct a network to uncover potential biomarkers for diagnostic reasons, prospective EDCs for preventative applications, and potential drugs for therapeutic purposes in early-stage CRC. Results To this end, we identified driver genes linked with early-stage colorectal cancer and used the R package WGCNA to design a co-expression network. Following that, modules were chosen, and possible biomarkers were identified using the Cytoscape software and the TCGA database. Then, using the comptox database, we identified probable EDCs and created an EDC-GENE network. Finally, we introduced EDCs with a high degree of risk. The drug-gene network was then reconstructed to find viable therapies for colorectal cancer in its early stages. The co-expression network was constructed using the 1108 driver Genes’ mRNA expression values of 70 early-stage CRC and 12 healthy control samples. The clustering results show that the overlapping gene set is divided into 27 modules. Our study identified five modules (indicated in dark green, dark orange, light cyan, royal blue, and purple) according to the average linkage hierarchical clustering and Zsummary less than 2. Then we find 17 high degree genes of these modules as potential biomarkers for diagnostic issues. Moreover, we explored 25 possible high degrees of Endocrine Disrupting Chemicals that affect the main genes of each module for preventing purposes. Finally, we identified 27 potential high degree drugs that affect the primary genes of each module as treating aims. Then, these biomarkers, EDCs, and drugs that may be tested as a basis for future research were introduced. Conclusions This research aimed to identify potential biomarkers for diagnostic purposes, prospective EDCs for prevention, and potential therapeutic agents in colorectal cancer in its early stages. These biomarkers, EDCs, and medications will aid in diagnosing, preventing, and treating colorectal cancer in its early stages.