Psoriasis is a multi-factorial disease represented by complex atomic scenes and cellular pathways that lead to abnormal cell development. The normal mixture has a clear target and limited cytotoxicity; in this sense, it can support the further development of new therapies for the treatment of this flexible disease. Berberine is an individual of the original berberine alkaloid family. It mainly exists in the roots, trunks and barks of various trees and has anti-psoriatic activity. In any case, according to the berberine organization, limited bioavailability and low assimilation rate are the two main obstacles, because only 0.5% of the ingested berberine is consumed in the small digestive tract, and this rate is when it enters the intestines. It is further reduced to 0.35%. Nano-based details are seen as the best way to increase the assimilation rate because substances accumulated at the nano-level can be quickly absorbed in the intestine. Useful methods based on nanotechnology have been developed to solve these problems to ultimately achieve greater sufficiency in the treatment of various diseases. The investigation introduced and essentially examined the anti-proliferative effects of berberine and nanotechnology-based repair technology for nano-scale transportation of berberine. Finally, we will thoroughly analyze and examine the current methods and promising viewpoints of the recent transportation of this alkaloid.