The aim of this randomized prospective study was to compare the efficacy of endoscopic versus standard microsurgical excision of pituitary adenomas, and to evaluate the merits and demerits of each approach. Twenty patients with a pituitary adenoma were randomly divided into two groups comprising of 10 cases each. Ten cases were operated by endoscopic endonasal trans-sphenoidal approach by endoscopic rhinologist (EETSS group) and other 10 cases were excised by microsurgical endonasal trans-sphenoidal approach by a neurosurgeon (SMETSS group). In both the groups complete excision was achieved in 50% of patients (unpaired t-test, p = 1.00). In EETSS group mean operative time was 64.5 +/- 19.16 min (range 50 - 100 min). In the SMETSS group, mean operative time was 75.5 +/- 18.48 min (range 55 - 120 min; unpaired t-test, p = 0.64, statistically not significant). In the EETSS group blood loss ranged between 100 and 190 ml (mean 100 +/- 42.16 ml). In the SMETSS group blood loss ranged between 50 and 250 ml (mean loss of 120 +/- 58.69 ml; unpaired t-test, p < 0.05, statistically significant). Postoperative nasoseptal complications were more common in SMETSS group (Chi-square test, p < 0.05, statistically significant). Endoscopic approach provides a wide surgical field and broad lateral vision making easier distinction of tumour tissue: gland and gland diaphragm interface. Thus, there is less blood loss and nasoseptal complications, whereas there was no statistically significant difference in operative time and complete tumour removal.

Dear Editor,We recently read with interest the editorial by Gattinoni et al. [1], conceptualizing 'type L' and 'type H' (typical acute respiratory distress syndrome, ARDS) phenotypes for COVID-19. We hypothesize that what the authors label a type L phenotype is actually a typical Stage 2/Stage 3 of COVID-19 pneumonia [2]. Like any other pneumonia, COVID-19 pneumonia can result in complications like severe ARDS; we believe that referring to this as a 'type H phenotype' may lead to confusion. Furthermore, we are hesitant to accept the authors' hypothesis concerning the mechanism of hypoxia in the so-called type L phenotype. Here is our reasoning.

This randomised, double-blind study was designed to compare the duration of analgesia and adverse effects following intrathecal administration of dexmedetomidine or clonidine, both with bupivacaine, in trauma patients. Ninety adult trauma patients of American Society of Anesthesiologists physical status I—II, scheduled for lower limb surgery under subarachnoid block, were randomly allocated to one of three groups. All groups received hyperbaric bupivacaine 0.5% 3 ml, to which was added saline 0.5 ml (Group B): clonidine 50 μg (Group C) or dexmedetomidine 5 μg (Group D). The onset and duration of sensory and motor blockade, severity of postoperative pain, time to first rescue analgesia and total analgesic requirement for 24 hours were noted. There was no significant difference in the onset time of the block but the duration of sensory and motor blockade was prolonged in Groups C and D, compared with Group B. The time to analgesia was significantly prolonged in Group D (824±244 minutes) compared with Group C (678±178 minutes; P=0.01), the latter being longer than Group B (406±119 minutes; P=0.0001). Postoperative pain scores were lower in Groups C and D compared with Group B. The requirement for rescue analgesia during the first 24 postoperative hours was significantly less in Groups C and D as compared to Group B (P=0.0001), but comparable between Group C and D (P=0.203). In conclusion, dexmedetomidine 5 μg added to intrathecal bupivacaine 15 mg produces longer postoperative analgesia than clonidine 50 μg among trauma patients undergoing lower limb surgery.

Tetrology of Fallot (TOF) is the most commonly encountered congenital cardiac lesion in pregnancy. Although there are controversies regarding safe anesthetic technique for parturient with TOF, we use low-dose sequential combined-spinal epidural anesthesia in such a case posted for Cesarean section and found that low dose (0.5 ml of 0.5%) intrathecal bupivacaine and fentanyl with sequential epidural bupivacaine supplementation was adequate for the performance of an uncomplicated Cesarean section with minimal side effects and good fetal outcome. Thus, though the choice of anesthesia can vary in such patients, low-dose sequential combined-spinal epidural can be a safe alternate to achieve good anesthesia with impressive cardiovascular stability.

This retrospective study evaluated perioperative outcomes of open partial nephrectomy (OPN), laparoscopic partial nephrectomy (LPN), and robot-assisted partial nephrectomy (RAPN) and identified predictive factors of Trifecta achievement for renal tumors that underwent partial nephrectomy (PN) in a single institutional cohort. The study involved patients who underwent PN from January 2011 to July 2018. Trifecta was defined as absence of perioperative complications, no positive surgical margins, and ischemia time <30 min. Fifty-five PN procedures were reviewed: 28 OPN, 14 LPN, and 13 RAPN. OPN, LPN and RAPN had similar median tumor size (5.75, 5.25, and 5 cm), nephrometry score (7, 6, and 6), and preoperative creatinine (1.09, 1.1, and 1.1 mg/dl, respectively). Blood loss was higher for OPN (550 ml) than for LPN (400 ml) and RAPN (300 ml), P = 0.042. Drain was removed after 6 days in OPN which was higher than LPN and RAPN (4.5 and 4 days, respectively), P = 0.008. OPN, LPN, and RAPN had similar median operative time (190, 180, and 180 min, respectively), P = 0.438. Median postoperative stay for OPN, LPN, and RAPN was 5, 6.5, and 10 days, respectively. Trifecta outcomes of 73.1%, 64.3%, and 61.53% were achieved in OPN, LPN, and RAPN, respectively, P = 0.730. It was concluded that Trifecta outcomes had no significant difference among OPN, LPN, and RAPN. LPN can produce as good results as RAPN. Keeping in mind the cost-effectiveness, LPN holds an important position in developing countries where expenditure by patient is a major factor.