Herein, we report a visible-light mediated organophotoredox-catalyzed Csp2-H alkylation of N-heteroarenes with dihydroquinazolines, from aliphatic ketones, under oxidative condition. This protocol represents a metal free approach to effectively construct C-C bond via Minisci-type reaction, formally activating native C-H bond of N-heteroarene and -C-C bond of readily available ketones. The mild nature of this method accommodates a large variety of N-heteroarenes as well as ketones, tolerating distinct functional groups.

A silver-catalysed oxidative sp2 C-H alkylation of N-heteroarenes with ketone-derived 2,3-dihydroquinazolinones at room temperature is developed. The combination of a metal catalyst and perdisulfate oxidant promotes the rarely explored thermal...

Basudev Sahoo was nominated to be part of this collection by EurJOC Board Member Ruben Martin; dedicated to Prof. Frank Glorius on the occasion of his 50 th birthday www.eurjoc.org