No abstract

The aim of the study is to identify cornulin (CRNN) protein expression associated with advancement of tongue squamous cell carcinoma (TSCC). A comparison of addictive (containing potential carcinogens) versus non-addiction causative agents was expected to allow detection of differences in CRNN expression associated with TSCC. Bespoke tissue microarrays (TMAs) were prepared and immunohistochemistry (IHC) performed to determine the changes in CRNN expression in epithelial cells of node-negative (pN-), node-positive (pN +) TSCC and non-cancer patients' oral tissues. TMAs were validated by performing IHC on whole diagnostic tissues. Chi-square test or Fisher's-exact tests were used to establish significant expression differences. Analogous analyses were performed for biomarkers previously associated with TSCC, namely collagen I alpha 2 (COL1A2) and decorin (DCN) to compare the significance of CRNN. Keratinisation and its level (low, extensive) were studied in relation to CRNN so that the extent of squamous differentiation could better be assessed. IHC immunoreactive score (IRS) clustered the patients based on weak/moderate (Low (IRS ≤ +3)) or strong (High (IRS ≥ +4)) expression groups. A low expression was observed in a larger number of patients in control proteins COL1A2 (77.3%), DCN (87.5%) and target protein CRNN (52.3%), respectively. Low CRNN expression was observed in TSCC where nodes were involved (pN+: mean 1.4 ± 2.1) (p = 0.248). Keratinisation (%) was low (0% ≤ 50%) in 42.2% and extensive (1% ≥ 50.0%) in 57.8% patients. In conclusion, our study suggested that Low CRNN expression was associated with grade and lymph node metastasis in TSCC. CRNN expression is independent of addiction, however potentially carcinogenic addictive substances might be aiding in the disease progression.

The research is financed by Asian Development Bank. No. 2006-A171(Sponsoring information) Abstract OBJECTIVE: To evaluate the lumbar disc herniation on magnetic resonance imaging (MRI) BACK GROUND: Lumbar disk herniation (LDH) is a common cause of low back pain in the world. The evidence has shown that the incidence of lumbar disc herniation (LDH) increases with age, weight lift and also depend on gender. In this cross-sectional descriptive study of LDH has been conducted to investigate the role of age in the incidence of LDH in elderly. The aim of the study is to investigate the relationship between the process of aging and the occurrence of LDH in old adults. Clinical studies have indicated that morphological characteristics of lumbar discs and signal intensity of patient's MRI image have close relationship with clinical outcome

Background: Obstructive jaundice is a common pathological problem that occurs when there is an obstruction to

Background: The leiomyosarcomas most commonly arise from smooth muscles of the uterus and gastrointestinal tract. The vascular origin of the leiomyosarcoma is very rare; however, veins are more frequently affected in such cases. Case Presentation: A 23-year-old boy presents with left thigh painless swelling. Subsequently, he underwent multimodality radiological examinations, which showed left superficial femoral vein mass, which later on histopathological evaluation came out to be grade III leiomyosarcoma of the superficial femoral vein. Management & Results: The patient was given chemotherapy, but unfortunately, after three cycles of chemotherapy patient developed pulmonary metastases. Currently, the patient is under palliative treatment. Conclusion: Primary vascular leiomyosarcomas are very rare entities. The knowledge of these rare tumors is essential for the reporting radiologists and clinicians to properly diagnose these aggressive tumors to prevent any delays in the management.