The current research aimed at designing mesoporous silica nanoparticles (MSNs) for a controlled coadministration of salicylic acid (SA) and ketoconazole (KCZ) to effectively treat highly resistant fungal infections. The sol−gel method was used to formulate MSNs, which were further optimized using central composite rotatable design (CCRD) by investigating mathematical impact of independent formulation variables such as pH, stirring time, and stirring speed on dependent variables entrapment efficiency (EE) and drug release. The selected optimized MSNs and pure drugs were subjected to comparative in vitro/in vivo antifungal studies, skin irritation, cytotoxicity, and histopathological evaluations. The obtained negatively charged (−23.1), free flowing spherical, highly porous structured MSNs having a size distribution of 300−500 nm were suggestive of high storage stability and improved cell proliferation due to enhanced oxygen supply to cells. The physico-chemical evaluation of SA/KCZ-loaded MSNs performed through powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and thermal gravimetric analysis (TGA) indicates absolute lack of any interaction between formulation components and successful encapsulation of both drugs in MSNs. The EE SA , EE KCZ , SA release, and KCZ release varied significantly from 34 to 89%, 36 to 85%, 39 to 88%, and 43 to 90%, respectively, indicating the quadratic impact of formulation variables on obtained MSNs. For MSNs, the skin tolerability and cell viability percentage rate were also having an extraordinary advantage over suspension of pure drugs. The optimized SA/KCZ-loaded MSNs demonstrated comparatively enhanced in vitro/in vivo antifungal activities and rapid wound healing efficacy in histopathological evaluation without any skin irritation impact, suggesting the MSNs potential for the simultaneous codelivery of antifungal and keratolyic agents in sustained release fashion.

Dilution with 5% dextrose provides earlier onset of axillary brachial plexus block with ropivacaine.

No abstract

No abstract

Objective: The aim of this study was to find out the role of depression in complete denture dissatisfaction and to determine frequencies of depression among the satisfied and dissatisfied patients. Study design: A cross sectional survey was carried out at Department of Prosthodontics, De’Montmorency College of Dentistry. Punjab Dental Hospital. The sample size was 80 edentulous patients having adequate maxillary and mandibular ridges. Methodology: The patients selected would be wearing complete dentures for the first time. All dentures were carefully designed. A socio-demographic form and depression rating questionnaire was filled by every participant involved in the study. After six months, satisfaction or dissatisfaction with the provided complete denture set was assessed through a separate questionnaire. The patients’ opinion concerning satisfaction with their dentures and depression was recorded and statistical analysis done. The results showed that 36.25% depressed versus 63.75% non-depressed. 28.75% were dissatisfied versus 71.25% satisfied. Conclusion: It was concluded that depression played a significant role in decreasing the satisfaction rating in first time denture wearers. Keywords: Depression, dissatisfaction, complete dentures,