Study purpose. The study aimed to investigate the social, physical, and mental well-being of people of all ages in Buriram province and developed physical activities that apply to local people of all ages. Materials and methods. To develop social cohesion in Sai To 5 Tai, Chanthopphet district, Buriram province, the study recruited 120 participants of all ages divided into 2 groups of 60 people each: 1) an experimental group was given a training program for training in Wai Kru Muay Thai 12 positions, 15 sequences 3 days/week, 30 minutes/day for 10 weeks; and 2) a control group performed their normal routine. The participants were assessed for their well-being in all ages using a questionnaire and for their physical fitness using field tests in pre-training and after training for 5 and 10 weeks. Research data were analyzed using mean, standard deviation, normal distribution test, parametric and non-parametric statistic test. Results. The results showed that after 10 weeks, the experimental group had social, physical, and mental well-being in all ages as well as physical fitness that developed in cardiovascular endurance, flexibility, muscle strength and endurance better than in the control group at a significance level of 0.05. Conclusions. The training program for training in Wai Kru Muay Thai 12 positions, 15 sequences can improve the well-being and physical fitness of people of all ages.