The LAFTI L10 probiotic strain did not have any significant effect on allergy outcomes. Allergic children showed a number of early differences in immune function including altered regulatory T-cell markers and innate immune function.

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Our complex world is changing at such a pace that we are struggling to address many of the global challenges ahead of us. As one of its symptoms, hybridisation means that fields, functions, characteristics and roles are increasingly combined and fused. This paper is an opening to the study of hybridisation, as an overlooked topic in the field of futures studies and foresight. We explore how hybridisation could be integrated into foresight through identification and interpretation of emerging issues and weak signals. As our case study, we examined how hybridisation manifests in the urban texture. We performed an anticipatory analysis of three hybrid urban spaces of pioneering architecture. We assumed a view to hybridity that considered diverse futures, images of the future, and open futures to detect what is opening or closing. Coming to terms with hybridisation and its expressions may inform action on anticipatory governance by improving the detection of opportunities, risks and crises. Deeper understanding of budding developments that removes ambiguity may be a nudge towards novel solutions and promote futures resilience.

This chapter builds upon the premise that a multiplex of shared and divergent Bio-Ethos -models of what would be a 'good' relationships among humans and other living beings -inform the actions humans take toward living nature and ecosystems. Global Warming and Environmental Change demand from people and our societies new ways of existing as part of living ecologies on this planet. In this setting, the Bioeconomy and Justice Project (BioEcoJust) aims to explore ethical troubles that could arise in the development of a global, pervasive, and dominant bioeconomy. This chapter demonstrates how a role-based futuring game piloted in the Bioeconomy and Justice project supports people in 'sensing and making sense' of emergent BioEthos. It presents and analyses the outcomes from the BioEcoJust Game session held at the 2019 World Futures Studies Federation Conference in Mexico City. The conceptual framework applied in the game interweaves theories of complexity, futures literacy, and scenarios as worldmaking, and operationalizes sensemaking tools developed in the earlier stages of the BioEcoJust project including BioWorlds, bioeconomy socio-technical domains, the Human-Nature-Technology triangle, and Bi-oEthos. The BioEcoJust Game pilot in Mexico City enabled its players to explore and critically assess the nuances and dimensions of an ethically troubled future situation and produce a new BioEthos which could be helpful to a unique set of roles for engaging the situation. While much of the literature concerning bioeconomy is concerned with the technical or social factors which can contribute to its development, little attention is paid to what larger ethical frameworks can support its just and fair evolution. The BioEcoJust Game emphasised 'keeping whole' the created worlds of a variety of roles responding to an imagined future situation and focused the participant's attention on the interface between assemblages of persons and their bounding conditions. The BioEcoJust Game can serve as a model for futuring games designed to help people develop skills for sensing and making sense of emergent BioEthos so they can apply these skills to develop a more just bioeconomy.

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