Background: The current study aimed to evaluate the role of gamma-amino butyric acid (GABA) in modulating histopathological and biochemical disturbances in the rat's small intestine following gamma radiation exposure. Results:The results showed that whole body gamma irradiation (6 Gy) of rats induced mucosal damage, hemorrhage, increased cellularity of the lamina propria layer with areas of complete ulcerations. Histopathological changes were associated with a significant increase in malondialdehyde (MDA) and advanced oxidation protein products (AOPPs). In parallel, a significant decrease in catalase (CAT) and glutathione peroxidase (GSH-Px) activities was demonstrated. Administration of GABA (200 mg/kg body weight GABA daily via gastric gavage for three consecutive weeks) after irradiation of rats has significantly improved the oxidant/antioxidant status which was associated with regeneration of the small intestinal cell structure. Conclusion: Gastric administration of GABA was found to offer an advantageous treatment against gamma irradiation-induced small intestine oxidative stress in rats, probably by utilizing ameliorative effects via its antioxidant and free radical-scavenging activities. Its mechanisms need to be further investigated.

Aim of the work-This study aimed to investigate the histological and histochemical changes in the lung tissue of male albino rats post exposure to gamma radiation and the possible therapeutic effect of both olive leaf extract and bone marrow mesenchymal stem cells. Matrerial and methods-The current study was carried out on 40 adult male albino rats (Sprague dawely strain); they were divided equally into 5 groups (C group: control rats; O group : rats treated with olive leaves extract(15 mg /kg body weight/daily) ; R group: rats exposed to a single dose of gamma-radiation(3 Gy); RO group: rats of this group treated with olive extract 15 mg /kg body weight/daily one week before and one week after irradiation; RS group: rats of this group irradiated with 3Gy then treated with bone marrow mesenchymal stem cells (BMSCs) 3×10 6 cells/ml suspension through caudal vein about 5h post radiation exposure. Histopathological and histochemical changes were studied. Results-Rats exposed to gamma radiation showed numerous histological and histochemical changes, these changes were ameliorated by using either olive leaf extract or bone marrow mesenchymal stem cells. BMSCs showed more obvious therapeutic effect than olive leaf extract. Conclusion-The present work showed that olive leaf extract or bone marrow mesenchymal stem cells (BMSCs) have lung tissue radiotherapeutic effects against whole body gamma radiation in male albino rats.

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The present study aimed to assess the radioprotective effects of curcumin in combination with quercetin against radiation-induced changes in some histopathological, immunohistochemical, and biophysical parameters. The current study rats had been grouped into control, curcumin, quercetin, gamma irradiated (8 Gy fractionated dose), curcumin pretreated irradiated, quercetin pretreated irradiated, and both curcumin and quercetin pretreated irradiated groups. Gamma radiation exposure resulted in hepatic and renal damage. Administration of curcumin along with quercetin before gamma radiation exposure reduced the liver and kidney damage caused by radiation, demonstrating the radioprotective effects of both curcumin and quercetin antioxidants through free radicals scavenging effects, P53, and TNF-α inhibition, and structural changes measured by Fourier Transform Infrared (FTIR). The cellular damage by gamma radiation is greatly mitigated by administration of curcumin and quercetin before radiation exposure.