Background: The present study was conducted for assessing the impact of fixed orthodontic treatment on salivary nickel levels. Materials & methods: A total of 20 subjects who were scheduled to undergo fixed orthodontic treatment were enrolled in the present study. Complete demographic details of all the subjects were obtained. A Performa was made and complete clinical findings of all the subjects were recorded. At baseline (during the start of fixed orthodontic treatment), salivary samples were obtained and salivary nickel levels were evaluated using an autoanalyzer. Same procedure was repeated on regular follow-ups and salivary nickel levels were assessed. All the results were recorded in Microsoft excel sheet and were analyzed by SPSS software.  Results: Mean salivary nickel levels at baseline, 6 months follow-up and 1 year follow-up was 8.9 μg/L, 11.3 μg/L and 8.5 μg/L respectively. Significant results were obtained while comparing the mean salivary nickel levels at different time intervals. Conclusion: It could be concluded that orthodontic therapy for longer durations with sstainless-steel archwires might elevate slightly, but significantly, salivary nickel levels.