Objective: The objective of this study was to evaluate the effective new phytocomponents from Calophyllum inophyllum ethanol leaf extract against breast cancer target protein of epidermal growth factor receptor (EGFR) using in silico docking studies. Methods:The identification of compounds was done by gas chromatography-mass spectrometry (GC-MS) analysis. The in silico docking studies were carried out using Discovery Studio 4.0 software. Results:The GC-MS analysis of ethanol leaf extract revealed the presence of eleven compounds. The docking analysis has exhibited moderate to potent inhibition with a range of dock score 3-55. 2H-Benzo(cd)pyrene-2,6(1,H)-dione, 3,5,7,10-tetrahydroxy-compound showed the dock score of 55.427. Conclusion:The results revealed out that the compounds present in C. inophyllum can inhibit the EGFR protein. The plant possesses anticancer potential because of the various bioactive compounds presence which is mainly responsible for anticancer activity.

Traditional healers possess a rich knowledge on the use of medicinal plants for the treatment of various diseases. Enicostemma axillare (Lam). Raynal is one plant, used by healer to treat gastric cancer or ulceration. We assessed the phytochemical components of leaf extract for its antibacterial activity, to add value and provide an evidencebase for their traditional use. The antibacterial potential of the leaf extract was tested against Helicobacter pylori using agar well diffusion method. The minimum inhibitory concentration (MIC) of ethanol extract exhibited the (MIC) against H. pylori ranged from 200µg/ml -250µg/ml followed by chloroform extract. Gas chromatography and mass spectrum (GC-MS) analysis confirms the occurrence of different components in the ethanol and chloroform leaf extract of the studied species.

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