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The pandemic has trembled the world with the massive outbreak, leaving the scientific fraternity in shambles. The SARS-CoV-2 strain took a heavy toll and led to the death of millions of people. In late 2020, various mutated strains of the virus surged the disease across the world. For the same, diverse methods were used around the globe in search of precise medication against the pandemic. Despite vaccination for viral disease prevention, the virus has spread without restraint, making the need for strong antiviral drugs- a need of the hour. Several techniques were used for the fabrication of a strong antiviral drug in different modes of remedies. Many countries utilized their conventional therapeutic knowledge against the virus, which comprises the use of indigenous phytochemicals with varied biological activities. The present review includes the virology, epidemiology, and different therapeutic procedures practiced globally to combat the viral disease and highlights different indigenous potent plants with biological activities, such as antiviral, antipyretic, immunomodulatory and antimicrobial. These plants are efficacious and can be explored further as prospective remedies for many other maladies affecting the world.