Amy E. Mason scite author profile

Background: P450 BM3 is a high activity enzyme with biotechnological potential. Results: Mutations perturbing P450 BM3's conformational state and active site facilitate human P450-like oxidation of the drug omeprazole. Conclusion: Conformational destabilization enables P450 BM3 to explore novel conformations and accept diverse substrates. Significance: "Gatekeeper" mutations that decrease the energetic barrier for transition to the substrate-bound state can reconfigure P450 BM3 specificity and reactivity.

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Chapter 8. Structure, Mechanism and Function of Cytochrome P450 Enzymes

McLean¹,

Girvan²,

Mason³

et al.

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Amy E. Mason

What makes a P450 tick?

Key Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate Bias

Chapter 8. Structure, Mechanism and Function of Cytochrome P450 Enzymes

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