This study utilized diffusion tensor imaging fiber tractography to examine the miscrostructural integrity of limbic and paralimbic white matter tracts in thirty-six children (Mean age=124 months) with histories of early deprivation, raised from birth in orphanages and subsequently adopted into the United States, compared to 16 age-matched typically developing children. We found increased mean diffusivity bilaterally in the arcuate fasciculus, and increased mean diffusivity and reduced fractional anisotropy bilaterally in the uncinate fasciculus and cingulum in children with early deprivation. Microstructural integrity of the left arcuate fasciculus and right cingulum was related to language and behavioral functioning, respectively. White matter abnormalities were also associated with length of deprivation and time in the adoptive home. Our findings suggest that white matter pathways, connecting limbic and paralimbic brain regions is abnormal in children with histories of early deprivation; with some pathways appearing more susceptible to early deprivation than others.

Perceived support primarily reflects the relationships among specific recipients and providers. These strong relational influences suggest a new approach to interventions: Match specific providers with specific recipients so that unusually supportive relationships emerge. For this approach to be successful, progress must be made on several basic research questions. For example, it must be possible to forecast the specific providers that recipients will perceive as unusually supportive (i.e., forecasting relational support). In 2 studies, support recipients had 3 or 5 conversations with the same providers and reported affect, provider supportiveness, and perceived similarity (Study 2 only) after each conversation. Relational support could be forecasted from recipients' reactions to a single, brief conversation with each provider, even after 4 months had elapsed.