There is a dearth of literature on best practices for managing clinical trials, and little is understood on the role of the clinical trial manager. The COVID-19 pandemic has brought this into focus, and the continuance of clinical trials worldwide has been catapulted into a state of uncertainty as countries enter lockdown to manage the spread of the virus. Participant retention is an ongoing issue in clinical trials, and the concern is that in the current pandemic environment, attrition will be an issue which could potentially jeopardise trial completion. The current situation has necessitated timely problem solving by the trial manager to ensure trials remain open, and most importantly, that participant safety, paramount in clinical trials, is monitored. The purpose of our study is to highlight key issues arising in the management of clinical trials during a pandemic from first-hand experience in a clinical research facility managing both academic and commercial clinical trials. We offer some practical guidance on solution implementation.

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At the timo when the cremation movement was in its infancy tho need for some immediate change in the mode of the disposal of the dead was manifest, and the evils of intramural burial everywhere acknowledged. Thirty years ago few of the cities of the old world had any common water-supply. The inhabitants for the most part depended upon wells. These were frequently contaminated, and often became sources of epidemics ; and it was much easier to lay the charge to some neighboring cemetery, than to the contamination of such wells by the sewage from neighboring houses.