In this paper, a systematic control strategy has been proposed for specific problems with the various key performance indicators of the high-power photovoltaic (PV) inverter when it connects to the grid. it proposes fast and accurate variable-step-size perturbation and observation combined with power prediction as a Maximum Power Point Tracking-based (MPPT) control strategy. To meet the requirements for low voltage ride through (LVRT), it proposes a strategy for LVRT control. It adopts an active method used for anti-islanding detection of reactive power disturbance so as to realize anti-islanding detection quickly. Finally, it carries out testing on the control strategy by means of an experimental platform with a 500 kW PV inverter to prove the effectiveness of the proposed control strategy.