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A concise and efficient solid‐phase synthesis of biaryl cyclic peptides containing a Phe–Tyr or a Tyr–Tyr linkage has been accomplished. The key steps include a Miyaura borylation of a resin‐bound 3‐iodotyrosine and a microwave‐assisted Suzuki–Miyaura reaction for the formation of the macrocycle. First, the feasibility of the solid‐phase Miyaura borylation of a 3‐iodotyrosyltripeptide was established. Then, the Suzuki–Miyaura reaction was applied to the cross‐coupling of linear 3‐boronotyrosine‐containing peptidyl resins with iodobenzene and with halogenated aromatic amino acids. Finally, this methodology was extended to the synthesis of biaryl cyclic peptides through the preparation of a linear peptidyl resin containing both the required boronate and halogenated derivatives, followed by a microwave‐assisted Suzuki–Miyaura macrocyclization.

Resin‐bound phenylalanine boronates were prepared by solid‐phase Miyaura borylation of 4‐iodophenylalanine peptides. Subsequent arylation through a Suzuki–Miyaura cross‐coupling was carried out using a variety of aryl halides under conventional heating and under microwave irradiation. Microwaves greatly enhanced the arylation, shortening thereaction time and providing the biaryl peptides in higherpurities.

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