No abstract

ETV6-RUNX1 is associated with the most common subtype of childhood leukemia. Pre-leukaemic clones carrying ETV6-RUNX1 oncogenic lesions are frequently found in neonatal cord blood, but only few ETV6-RUNX1 carriers develop pB-ALL. The highly demanding and pending challenge is to reveal the multistep natural history of ETV6-RUNX1 pB-ALL, because it can offer non-toxic prophylactic interventions to preleukemic carriers. However, the lack of a genetically engineered ETV6-RUNX1 mouse model mimicking the human pB-ALL has hampered our understanding of the pathogenesis of this disease. This rule has now been broken in a study of the effect of the ETV6-RUNX1 oncogene in cancer development in a mouse model in which oncogene expression is restricted to the stem cell compartment. In this article, we review the different attempts to model this disease, including the recent representative success stories and we discuss its potential application to both identify etiologic factors of childhood ETV6-RUNX1 pB-ALL and prevent the conversion of a preleukemic clone in an irreversible transformed state.

The light steel frame walls are mostly used for non-load bearing applications. The light steel framed walls are made with studs and tracks that require fire protection, normally achieved by single plasterboard, by composite protection layers or by insulation of the cavity. The partition walls are fire rated to resist by integrity and insulation. Seven small-scale specimens were tested to define the fire resistance of non-load bearing light steel frame walls made with different materials. All tests were validated using two-dimensional numerical models, based on the finite-element method, the finite-volume method and hybrid finite-element method. A good agreement was achieved between the numerical and the experimental results from fire tests. The fire resistance increases with the number of studs and also with the thickness of the protection layers. The hybrid finite-element method solution method looks to be the best approximation model to predict fire resistance.

Light steel frame (LSF) (LSF) and prefabricated panels are widely used in loadbearing walls, with direct application to steel framed buildings. These walls are made with steel cold formed sections (studs and tracks) using gypsum plasterboard and other material layers attached to the flanges and sometimes insulation material in the cavities. The fire resistance is usually provided by one or more layer of materials and or by the cavity insulation. This investigation evaluates the fire resistance of the loadbearing walls, from the point of view of insulation (I) and loadbearing capacity (R). Experimental results obtained from partition walls were used into the numerical model to accurately preview the cracking, falling off and the ignition of combustible material. The numerical model was validated under the same fire conditions. The loadbearing capacity is determined using this hybrid model. This model is able to predict an accurate fire resistance for any load level, taking into account the brittle behaviour of gypsum panels and the