To characterize the profile of non-AIDS-related comorbidities (NARC) in the older HIV-1infected population and to explore the factors associated with multiple NARC. Methods: This was a multicentre, cross-sectional study including HIV-1-infected patients aged !50 years, who were virologically suppressed and had been on a stable antiretroviral therapy (ART) regimen for at least 6 months. A multiple regression model explored the association between demographic and clinical variables and the number of NARC. Results: Overall, 401 patients were enrolled. The mean age of the patients was 59.3 years and 72.6% were male. The mean duration of HIV-1 infection was 12.0 years and the median exposure to ART was 10.0 years. The mean number of NARC was 2.1, and 34.7% of patients had three or more NARC. Hypercholesterolemia was the most frequent NARC (60.8%), followed by arterial hypertension (39.7%) and chronic depression/anxiety (23.9%). Arterial hypertension and diabetes mellitus were the most frequently treated NARC (95.6% and 92.6% of cases, respectively). The linear regression analysis showed a positive relationship between age and NARC (B = 0.032, 95% confidence interval 0.015-0.049; p = 0.0003) and between the duration of HIV-1 infection and NARC (B = 0.039, 95% confidence interval 0.017-0.059; p = 0.0005). Conclusions: A high prevalence of NARC was found, the most common being metabolic, cardiovascular, and psychological conditions. NARC rates were similar to those reported for the general population, suggesting a larger societal problem beyond HIV infection. A multidisciplinary approach is essential to reduce the burden of complex multi-morbid conditions in the HIV-1-infected population.

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This study is focused on the prevalent NS5 coding region resistance-associated substitutions (RASs) in DAA-naive genotype (GT)1 HCV-infected patients and their potential impact on success rates. Plasma RNA from 81 GT1 HCV-infected patients was extracted prior to an in-house nested RT-PCR of the NS5 coding region, which is followed by Sanger population sequencing. NS5A RASs were present in 28.4% (23/81) of all GT1-infected patients with 9.9% (8/81) having the Y93C/H mutation. NS5B RASs showed a prevalence of 14.8% (12/81) and were only detected in GT1b. Overall 38.3% (31/81) of all GT1 HCV-infected patients presented baseline RASs. The obtained data supports the usefulness of resistance testing prior to treatment since a statistically significant association was found between treatment failure and the baseline presence of specific NS5 RASs known as Y93C/H (p = 0.04).

ResumoAborda o gerenciamento da política de desenvolvimento de materiais informacionais nas bibliotecas universitárias. Enfatiza a necessidade de as instituições estabelecerem normas e padrões que orientem o processo decisório, a fim de determinar a conveniência de se adquirir, manter e descartar coleções. Finaliza relacionando os critérios de seleção para formação ideal de um acervo, que atenda às reais necessidades da comunidade acadêmica. Palavras-chaveBiblioteca universitária. Desenvolvimento de coleções. Política de seleção. Materiais informacionais -gerenciamento. COLLECTION DEVELOPMENT IN UNIVERSITY LIBRARIES AbstractStudies the management related to the development of informative material in university libraries. Emphasizes the need that institutions have to establish norms and patterns to guide the decision making process, in order to determine the convenience to acquire, maintain and discard collections. Finalizes relating the ideal selection criteria to organize an asset, which provides the real necessities of the academic community. 2 1 INTRODUÇÃO No cenário atual, a sociedade da informação é marcada pelo fluxo constante de informações que possibilitam a produção de novos conhecimentos, em virtude do grande volume informacional e do desenvolvimento tecnológico, podendo, assim, atuar nas várias áreas do conhecimento, contribuindo na tomada de decisão nos vários grupos sociais. De acordo com Dias e Pires (2003), o fornecimento de informações é a principal função social dos serviços de informação. Le Coadic (1996, p.5) define informação como: "um conhecimento inscrito (gravado) sob a forma escrita (impressa ou numérica), oral ou audiovisual". A informação empregada, nesse contexto, envolve diversos tipos de fontes de informações: artigos de periódicos, jornais, monografias, dissertações, teses, relatos de experiências, obras de referências (dicionários, enciclopédias etc), materiais especiais (fotos, partituras musicais, atlas etc), bases de dados etc. No limiar das últimas décadas, a informação tornou-se a mais poderosa força de transformação do homem, encontrando-se presente no cotidiano do indivíduo através das relações sociais, econômicas e culturais e, adquirindo, neste sentido, um caráter decisivo para o alcance da cidadania, das metas e dos objetivos propostos pelo próprio homem, que cria um vínculo de dependência com a informação para sua melhor adaptação ao meio em que vive. A informação, quando usada sabiamente, contribui como instrumento formador da consciência crítica do indivíduo, podendo levá-lo à conquista do sucesso intelectual e profissional, caso contrário, pode levá-lo ao fracasso e à própria estagnação. Barreto (2003) reforça essa idéia ao afirmar que a informação, quando assimilada adequadamente, gera novo conhecimento, alterando o estoque mental de informações do indivíduo e traz ganhos ao seu progresso e ao desenvolvimento do seu grupo.A informação hoje adquire uma característica de mercadoria, ou seja, algo que pode ser capitalizado e que proporciona diversidade de oportunidades; ...

To characterize the HIV-2 integrase gene polymorphisms and the pathways to resistance of HIV-2 patients failing a raltegravir-containing regimen, we studied 63 integrase strand transfer inhibitors (INSTI)-naïve patients, and 10 heavily pretreated patients exhibiting virological failure while receiving a salvage raltegravir-containing regimen. All patients were infected by HIV-2 group A. 61.4% of the integrase residues were conserved, including the catalytic motif residues. No INSTI-major resistance mutations were detected in the virus population from naïve patients, but two amino acids that are secondary resistance mutations to INSTIs in HIV-1 were observed. The 10 raltegravir-experienced patients exhibited resistance mutations via three main genetic pathways: N155H, Q148R, and eventually E92Q - T97A. The 155 pathway was preferentially used (7/10 patients). Other mutations associated to raltegravir resistance in HIV-1 were also observed in our HIV-2 population (V151I and D232N), along with several novel mutations previously unreported. Data retrieved from this study should help build a more robust HIV-2-specific algorithm for the genotypic interpretation of raltegravir resistance, and contribute to improve the clinical monitoring of HIV-2-infected patients.