Currently, most mining companies conduct chemical analyses by X-ray fluorescence performed in the laboratory to evaluate the quality of Fe ore, where the focus is mainly on the Fe content and the presence of impurities. However, this type of analysis requires the investment of time and money, and the results are often available only after the ore has already been sent by the processing plant. Reflectance spectroscopy is an alternative method that can significantly contribute to this type of application as it consists of a nondestructive analysis technique that does not require sample preparation, in addition to making the analyses available in more active ways. Among the challenges of working with reflectance spectroscopy is the large volume of data produced. However, one way to optimize this type of approach is to use machine learning techniques. Thus, the main objective of this study was the calibration and evaluation of models to analyze the quality of Fe from Sinter Feed collected from deposits in the Carajás Mineral Province, Brazil. To achieve this goal, machine learning models were tested using spectral libraries and X-ray fluorescence data from Sinter Feed samples. The most efficient models for estimating Fe were the Adaboost and support vector machine and our results highlight the possibility of application in the samples without the need for preparation and optimization of the analysis time, providing results in a timely manner to contribute to decision-making in the production chain.