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Virtual poster abstracts n = 25) and small for gestational age (SGA, n = 25) based on birth weight < 3rd centile and/or abnormal cerebroplacental ratio and/or uterine artery Doppler. Congenital or chromosomal abnormalities and perinatal infection were excluded. CCFL and TL measures were blindly assessed in a sagittal plane obtained by transvaginal ultrasound at 32 weeks of gestation. Images were processed offline by manual measurements. We used t-test and ANOVA for analysis between variables. Comparison among groups was performed by lineal regression analysis adjusted by gestational age at NSG, occipitofrontal diameter, and maternal smoking as covariates. Results: Small fetuses showed significantly shorter CCFL (small fetuses: 43.7 vs AGA: 44.9 mm; P = 0.002) and TL (small fetuses: 9.4 vs AGA: 10.4 mm; P < 0.001). Both SGA and IUGR showed significant changes in CCFL with linear tendency across the groups. TL was also significantly shorter in both IUGR and SGA groups compared with AGA (figure 1). Conclusions: Small fetuses showed a significantly shorter CCFL and TL. This data supports the potential value of midbrain measurements by ultrasound as biomarkers of brain development. Further studies correlating these structures with post-natal functional tests and follow-up are needed.

Virtual poster abstracts which a fetal growth scan was performed at 34 +0/7 to 37 +0/7 weeks of gestation. Composite adverse neonatal outcome at discharge was defined by the presence of at least one of the following: birthweight >4,000 g, neonatal hypoglycemia requiring glucose 5% intravenous infusion, and shoulder dystocia not resolved by McRoberts' manoeuvre. Results: Population: 225. Characteristics of pregnancies with normal or adverse neonatal outcome at discharge are shown in table 1 (median values are reported). Binary logistic regression showed that ultrasound estimated fetal weight Z score (adjusted odds ratio (aOR) 6.82; p < 0.0001) and 1-hour maternal glucose level (aOR 1.02; p = 0.027) were associated with adverse neonatal outcomes. Conclusions: Estimated fetal weight at 34 +0/7 to 37 +0/7 and one-hour maternal glucose level appear to be the main determinants of neonatal adverse outcome at discharge in this neonatal population from pregnancies complicated by gestational diabetes. VP36.20: Table 1.