This study has as research line Nursing Education and predominant area Nursing in Child and Adolescent Health Care. Where we will address as a theme the complications related to the handling of the picc catheter (peripherally inserted central catheter) in the NEONATAL ICU. The object of the study is the Iatrogenies related to the management of PICC in UTINEO. The interest in researching the subject arose after a technical visit made in a hospital unit of the public network in the ICUNEO sector, where it was observed the use of the catheter and its implementation, being carried out by the nurse at the bedside, a fact that motivated us to carry out the study, since it brings great benefits to neonates. Qor being an invasive procedure does the correct manipulation if necessary to avoid contamination, which caused us to question whether complications in handling the PICC catheter can be avoided? Through this questioning we are ready to conduct a research that aims to identify the main complications that cause the interruption of treatment in neonates. Metodologically is a quantitative research, where the exploratory-descriptive method of bibliographic typology was used. Conclusion Given what was exposed and explored during the research trajectory, we realized that it is necessary to invest in training and continuing education programs, as well as establishment of protocols and care that allow better monitoring of the occurrence of complications related to the insertion and handling of PICC.