Background. The standard treatment for ampullary adenocarcinoma is pancreaticoduodenectomy. Identification of preoperative risk factors might help the clinician to select patients fit for resection and potentially decrease morbidity and mortality after PD. We conducted a cohort study to determine the preoperative factors related to 90-day severe morbidity and mortality after PD. Methods. We conducted a retrospective cohort study in patients with a diagnosis of ampullary adenocarcinoma who underwent an open PD between January 2010 and December 2019 at our tertiary centre. Results. Independent preoperative predictors of mortality were the albumin-bilirubin (ALBI) grade 3 (OR: 21.7; CI 95: 2.1–226.9; p = 0.01 ) and the estimated glomerular filtration rate (eGFR) <90 mL/min/1.73 m2 (OR: 17.7; CI 95: 1.8–172.6; p = 0.013 ). The eGFR <90 mL/min/1.73 m2 (OR = 6.6; CI 95: 1.9–23.4; p = 0.003 ) and prothrombin time (OR = 1.5; CI 95; 1.1–2.1; p = 0.005 ) were independent predictors for severe morbidity. Conclusion. These findings suggest that baseline renal function measured by the eGFR and liver function categorized with the ALBI grading are predictors of severe morbidity and mortality. Thus, they should be considered when selecting patients for PD or the use of neoadjuvant treatments. Further research is warranted.

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Horiz Med 2015; 15 (1): Características epidemiológicas y clínicas de las cardiopatías congénitas en menores de 5 a os del Hospital Almanzor Aguinaga Asen o. Enero Diciembre 2012. 1,a 1,2,b 1,2,c 1 2 a b c RESUMEN Material y Métodos: quirúrgico. y según tipo, acianóticas, siendo comunicación interventricular en mayor proporción, y su tratamiento prevalece el Palabras clave: Epidemiological and clinical characteristics of congenital cardiopathies in children under 5 in Hospital ABSTRACT Material and Methods: Quantitative descriptive cross sectional study design, the chosen were children under 5 years who database in Excel 2010.type, being the interventricular communication most frequently, and treatment prevails conservative, observation and

We report the case of a 75-year-old female patient with a big tumour in the lower rectum with intestinal obstruction and lower gastrointestinal bleeding history who underwent a tumour biopsy under laparotomy and end colostomy at another hospital in Peru. She came to our institution for clinical evaluation with a pathology result of a rectal gastrointestinal stromal tumour. An extra elevator abdominoperineal resection was performed with tumour-free margins. The histology confirmed a high-grade (G2) rectal gastrointestinal stromal tumour with a mitotic index of 27/50. DOC-1 (+) and CD117 (+) in immunohistochemistry. Genomic DNA was extracted from the paraffin-fixed tumour sample, and c.1504_1509dupGCCTAT (p.Ala502_Tyr503dup) mutation was detected in exon 9 of the KIT gene. Imatinib 400 mg per day for 3 years was indicated as adjuvant treatment. Currently, she has a disease-free survival of 12 months.

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