In the present study, different aerial parts from twelve Amazonian plant species found in the national Institute for Amazon Research's (InpA's) Adolpho Ducke Forest Reserve (in Manaus, Amazonas, Brazil) were collected. Separate portions of dried, ground plant materials were extracted with water (by infusion), methanol and chloroform (by continuous liquidsolid extraction) and solvents were removed first by rotary evaporation, and finally by freeze-drying which yielded a total of seventy-one freeze-dried extracts for evaluation. These extracts were evaluated initially at concentrations of 500 and 100 µg/ mL for in vitro hemolytic activity and in vitro inhibition of platelet aggregation in human blood, respectively. Sixteen extracts (23 % of all extracts tested, 42 % of all plant species), representing the following plants: Chaunochiton kappleri (Olacaceae), Diclinanona calycina (Annonaceae), Paypayrola grandiflora (Violaceae), Pleurisanthes parviflora (Icacinaceae), Sarcaulus brasiliensis (Sapotaceae), exhibited significant inhibitory activity towards human platelet aggregation. A group of extracts with antiplatelet aggregation activity having no in vitro hemolytic activity has therefore been identified. Three extracts (4 %), all derived from Elaeoluma nuda (Sapotaceae), exhibited hemolytic activity. none of the plant species in this study has known use in traditional medicine. So, these data serve as a baseline or minimum of antiplatelet and hemolytic activities (and potential usefulness) of non-medicinal plants from the Amazon forest. Finally, in general, these are the first data on hemolytic and inhibitory activity on platelet aggregation for the genera which these plant species represent. Testes in vitro de plantas Amazônicas para atividade hemolítica e inibição da agregação plaquetária em sangue humano RESUMO no presente estudo, partes aéreas obtidas de doze (12) espécies vegetais da Amazônia encontradas na Reserva Florestal Adolpho Ducke (localizada na cidade de Manaus, Estado do Amazonas, Brasil) do Instituto nacional de pesquisas da Amazônia foram coletadas, secadas e moídas. porções dos materiais vegetais em pó foram extraídas com água (por infusão), metanol e clorofórmio (por extração líquido-sólido contínua) e os solventes foram removidos por evaporação rotatória e finalmente liofilização, forneceram um total de setenta e one (71) extratos liofilizados. Esses extratos foram avaliados inicialmente para atividade hemolítica in vitro e atividade inibitória da agregação plaquetária em sangue humano in vitro em concentrações de 500 e 100 µg/ mL, respectivamente. Dezesseis (16) extratos (23 % dos extratos testados, 42 % das espécies vegetais) representando as seguintes plantas, apresentaram inibição significativa frente a agregação de plaquetas humanas in vitro: Chaunochiton kappleri (Olacaceae), Diclinanona calycina (Annonaceae), Paypayrola grandiflora (Violaceae), Pleurisanthes parviflora (Icacinaceae), Sarcaulus brasiliensis (Sapotaceae). Como principal resultado, um grupo de extratos apresentando ...
The COVID-19 pandemic is an unexpected historical event with an impact on all aspects of life - especially those of an occupational and mental nature. In a few months, it has altered daily life and social relations and, in addition to social distancing, isolation or quarantine, the world's population has to live with fear, insecurity and human and economic losses. Young people, particularly young women with a psychiatric history and no social support, are more vulnerable to the psycho-emotional consequences of the pandemic. The objective of this study was to observe the impact of COVID-19 on the mental health of students and their coping strategies. This was an observational study with a quantitative and cross-sectional method. The sample consisted of health students from a public university in the state of Paraíba, Brazil. Participants were recruited from the digital platforms in June 2020, a period of social isolation. The link to the Google forms questionnaire was made available on Instagram and WhatsApp. A total of 56 students, most of them women, answered the questionnaire. The most prevalent symptoms during social isolation were anxiety (76.8%), concern (71.4%), fear (62.5%), insomnia (60.7%) and sadness (55.4%). Anxiety, depression, and hopelessness symptoms were more prevalent in younger female students with negative health perception. Complementary therapies and conversations with friends and family stand out as coping strategies. Mental health demands a convergence of efforts and institutional actions are needed to manage the psycho-emotional and neurobiological impact of COVID-19 in an integrated and integral way.
Objetivo: Discorrer sobre as experiências no processo de ensino e monitoria remotos, com o olhar na promoção da saúde, em tempos de pandemia. Método: Estudo do tipo relato de experiência com abordagem qualitativa, descritiva e exploratória, realizado a partir das vivências e interações promovidas através dos encontros síncronos e assíncronos entre docente, discente-monitor e discentes do Curso de Enfermagem, na disciplina de Metodologia do Trabalho Científico, com carga horária de 30 horas, do Departamento de Enfermagem em Saúde Coletiva da Universidade Federal da Paraíba (UFPB). Resultados: As atividades foram planejadas e organizadas em três etapas principais, acolhimento, desenvolvimento do conteúdo programado e encerramento. Desenvolveram-se de forma síncrona e assíncrona, utilizando as seguintes plataformas e aplicativos: Google (Meet, Forms, Docs e Agenda), Moodle Classes, e-mail e WhatsApp. A maioria dos (15) discentes era do sexo feminino, treze (13) foram aprovados (87%). Em todos os encontros síncronos foram utilizados diferentes recursos culturais e estratégias para o cuidado e promoção da saúde (músicas, poemas, parábolas e dinâmicas de quebra gelo) para acolher, desenvolver e encerrar as atividades. A monitoria foi dinâmica e criativa utilizando tecnologias de informação e comunicação. Considerações Finais: O ensino e a monitoria com um olhar no cuidado e promoção da saúde, foram um desafio em tempos de pandemia, uma experiência única e importante componente de contribuição para o êxito do processo de formação acadêmica no formato de ensino remoto. Desenvolveu-se um novo olhar e modo de fazer que permitiu avançar e cuidar no processo de ensino aprendizagem.
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