The aim of this study is to highlight the need for sustainable urban development by reviewing the different Indicator Systems (SI) and contrasting them with those factors that have had a correlation in the spread of the virus in order to detect its deficiencies. This research carries out an urban diagnosis and analyzes the influence of these factors in order to detect deficiencies and propose a new IS adapted to current needs. Lastly, the new SI is validated through its practical application in one of the Autonomous Communities most affected by the pandemic in Spain. It is concluded that most of the factors causing a worse incidence of the virus are hardly evaluated by the existing IS. The practical analysis shows that there are deficiencies in urban design, resulting in poor environmental quality and urban morphology.