The grafting of monochlorotriazinyl-β-cyclodextrin on cellulosic hemp materials provides hosting cavities that can include a large variety of chemicals for specific antimicrobial finishing. The yarns obtained after processes with simultaneous phases of wet-spinning and grafting have adequate physico-mechanical characteristics. The monochlorotriazinyl-β-cyclodextrin solution causes an increasing of hemp fibers adherence leading to yarns tenacities and elongations enhancing. Four compounds (ferulic acid, caffeic acid, ethyl ferulate and allantoin) have been included into the cavities of monochlorotriazinyl-β-cyclodextrin grafted on hemp fibers. The included derivatives have been characterized by infrared spectroscopy tests which have confirmed that the included components are efficiently hosted in the cyclodextrin nanocavities. The antimicrobial properties of the samples were evaluated by microbiological analysis which has shown that the sanogenetic properties of the hemp fibers are significantly modified by the chemical treatments.