This study presents the design of novel composites nanogels, based on poly(ethylene glycol) diacrylate and natural zeolite particles, that are able to act as materials with controlled drug delivery properties. Natural zeolite–nanogels composite, with varying zeolite contents, were obtained by an inverse mini-emulsion technique and loaded with 5-fluorouracil, a widely used chemotherapeutic drug. Herein, the possibility of adjusting final properties by means of modifying the preparation conditions was investigated. The prepared composite nanogels are characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). In light of this tunable drug-loading capability, swelling behaviour, and cytotoxicity, these composite nanogels could be highly attractive as drug reservoirs.

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Molecular imprinting (MI) is the most available and known method to produce artificial recognition sites, similar to antibodies, inside or at the surface of a polymeric material. For this reason, scholars all over the world have found MI appealing, thus developing, in this past period, various types of molecularly imprinted polymers (MIPs) that can be applied to a wide range of applications, including catalysis, separation sciences and monitoring/diagnostic devices for chemicals, biochemicals and pharmaceuticals. For instance, the advantages brought by the use of MIPs in the sensing and analytics field refer to higher selectivity, sensitivity and low detection limits, but also to higher chemical and thermal stability as well as reusability. In light of recent literature findings, this review presents both modern and dedicated methods applied to produce MIP layers that can be integrated with existent detection systems. In this respect, the following MI methods to produce sensing layers are presented and discussed: surface polymerization, electropolymerization, sol–gel derived techniques, phase inversionand deposition of electroactive pastes/inks that include MIP particles.