Acute Myocardial Infarction (MI) can be detected through Reconstructed Phase Space (RPS) parameters. The RPS is dependent on a time delay (τ ) that can be a fixed or an optimal value based on the mutual information between a vectorcardiogram lead and its delayed version. This paper aims to assess the effect of an optimized time-delay in the detection of MI in the anterior wall using RPS parameters. For optimal τ values the sensitivity, specificity, accuracy and AUC obtained were: 64.7%, 63.2%, 57.8% and 62.3%, respectively; while for a fixed τ value were, respectively, 81.3%, 74.5%, 64.9% and 70.1%.