Introdução: A Diálise Prolongada de Baixa Eficiência (DPBE), terapia híbrida de substituição da função renal, surgiu como alternativa aos métodos intermitentes e contínuos de diálise na insuficiência renal aguda. Objetivo: Demonstrar a experiência com a DPBE no tratamento de pacientes da Unidade de Terapia Intensiva (UTI) e do Centro de Terapia Semi-Intensiva (CTSI) do Hospital de Clínicas da Universidade Federal do Paraná (HC-UFPR) entre Abril/2013 e Outubro/2014. Materiais e Métodos: As informações foram coletadas dos prontuários de pacientes da UTI/CTSI, submetidos à DPBE (sistema GENIUS®) com duração de 8 horas. Incluíram-se dados demográficos como: sexo, idade, presença de diabetes mellitus (DM), hipertensão arterial sistêmica (HAS) e doença renal crônica (DRC), uso de drogas vasoativas (DVA) e de ventilação mecânica (VM). Foram obtidas dosagens plasmáticas de ureia, creatinina, sódio, potássio, fósforo, magnésio, bicarbonato, glicose, saturação de O2 e pressão parcial de O2 e de CO2 em três momentos: antes, na 4ª hora e após o procedimento (8ª hora). Resultados: 41 DPBE foram realizadas em 17 pacientes, 8 mulheres. 88% estavam em VM e DVA. A taxa de mortalidade no internamento foi de 76%. 35% apresentavam DM, quase 60%, HAS, e em torno de 17%, DRC. O percentual médio de redução de ureia (%) foi de 62 ± 8,4. O fósforo (mg/dL) reduziu significativamente entre primeira (4,09l ± 2,28) e oitava horas (2,03 ± 1,04), p<0,05. Conclusão: A DPBE demonstrou-se efetiva e segura em relação à diálise convencional, havendo necessidade de reposição de fósforo durante o tratamento devido à hipofosfatemia observada na maioria dos casos.
Introduction: Allergic rhinitis is an inflammatory condition of the inside of the nose, mediated by Immunoglobulin E, in response to an inhaled allergen. Clinically, it presents with nasal obstruction, runny nose, nasal and/or eye itching, and sneezing. For its symptomatic treatment, environmental control is essential and nasal steroids are the gold standard in the adult and pediatric population. Another form of treatment is immunotherapy, changing the response to the allergen via the immune tolerance mechanism. Subcutaneous immunotherapy (SCIT) is applied weekly to monthly, in contrast to sublingual immunotherapy (SLIT), which is performed daily by the patient. For an effective treatment of chronic disease, the period of treatment and discipline in maintaining it must be respected. Objective: Analyze the main reasons why the patient gives up treatment with sublingual immunotherapy. Methods: This prospective and linear study evaluated patients at the IPO Hospital (Instituto Paranaense de Otorrinolaringologia, Curitiba, Brazil) who were undergoing treatment with sublingual immunotherapy for allergic rhinitis and who, for some reason, discontinued the recommended treatment. Results: The study sample consisted of 148 patients, 79 women and 69 men. The mean duration of treatment for patients who dropped out was 8.3 months. The cost was the most cited reason, which was mentioned by 47.3% of patients; followed by irregularity of use and absence of improvement with treatment, both with 23% each. The presence of side effects was included as a reason by 9.5% and still, 25% of respondents cited several other reasons as obstacles to treatment. Conclusion: The present study concluded that the main barriers found for treatment adherence are long treatment duration, cost, and regularity of use.
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