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Objectives: This study aimed to evaluate oral health and factors that may influence it in individuals with Asperger’s syndrome. Methods: This observational cross-sectional study was divided into two stages: a question- naire and an oral examination, using the decayed-missing-filled index, the gingival index, and the simplified oral hygiene index. Data were analyzed using SPSS® software (version 26.0), considering a significance level of 0.05. After verifying the non-normality with the Kolmogorov-Smirnov test, the Mann-Whitney and Kruskal-Wallis tests were used. Results: The investigation included 23 adults with Asperger syndrome. A decayed-miss- ing-filled index of 2.65(±2.81), a gingival index of 1.06(±0.36) and a simplified oral hygiene index of 2.08(±0.73) were found. Most respondents (60.8%) brushed their teeth twice a day. Individuals with higher brushing frequency and those who recently had an oral appointment had lower calculus deposits (p=0.038 and p=0.021, respectively). Conclusions: The individuals had a low dental caries prevalence, mild gingival inflammation, and a fair oral hygiene status. Although there are factors capable of influencing the oral health of these individuals, good results can be obtained if adequate oral hygiene habits are maintained, namely brushing twice a day.