The transport of three toxins moving from the blood stream into the ducts of the mammary glands is analyzed in this work. The model predictions are compared with experimental data from the literature. The utility of the model lies in its potential to improve our understanding of toxin transport as a pre-disposing factor to breast cancer. This work is based on a multi-layer transport model to analyze the toxins present in the breast milk. The breast milk in comparison with other sampling strategies allows us to understand the mass transport of toxins once inside the bloodstream of breastfeeding women. The multi-layer model presented describes the transport of caffeine, DDT and cimetidine. The analysis performed takes into account the unique transport mechanisms for each of the toxins. Our model predicts the movement of toxins and/or drugs within the mammary glands as well as their bioaccumulation in the tissues.

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Obesity, traditionally defined as excess body fat, is a non-communicable chronic inflammatory disease highly prevalent in both sexes, in all age groups, and in different regions globally, which is frequently associated with an increased risk of metabolic and cardiovascular morbidity and mortality. During the last decades, evidence has been growing that suggests the existence of a phenomenon that is currently known as the “obesity paradox”, which exposes that individuals who are overweight or obese have a lower risk of mortality from all causes, an effect that extends to those patients with cardiovascular diseases (CVD), in whom mortality from CV causes is also decreased.