Background: D-dimer is a fibrin degradation product present in the blood after infection, thrombosis, or pregnancy. Covid-19 is a prothrombotic inflammatory condition, where D-dimer is often detectable showing higher levels in severe COVID-19 cases. The usefulness of D-dimer for the diagnosis of pulmonary embolism (PE) in SARS CoV2 has not been determined.Aim: To determine the operational characteristics of D-dimer as a diagnostic method for PE in patients with COVID-19 treated at a university hospital in Bogotá, Colombia.Methods: Diagnostic test study that included data from patients with COVID-19 with suspected PE who were screened with the index test (D-dimer measured by turbidimetric immunoassay technique) and reference test (Angiotomography of pulmonary arteries). Results: Among the 209 patients analyzed, the prevalence of PE was 14.4%, D-dimer levels were significantly higher in the group of PE cases (2888 vs. 1114 ng/Dl; p=0.002). 80% of PE cases were submassive and 53% segmental. The operating characteristics for the reference cut-off point of the technique (>499ng/mL) were Sensitivity: 93.9%, Specificity: 8.9%, Positive predictive value: 14.7%, Negative predictive value: 8.9%, proportion of false positives: 91.1%, a Youden J- index of 0.02. The area under the receiving operating curve was 0.684. The coordinates of the curve showed a Youden J- index of 0.367 for a value of 2.281 ng/mL (4.5 times the reference value), using this cut-off point, we obtained a sensitivity of 60%, a specificity of 76%, PPV of 30%, NPV of 92%, and a proportion of false Negatives of 40%.Conclusion: D-dimer does not have appropriate characteristics to be used alone for the diagnosis PE in patients with severe COVID-19. It can be used as part of a rational diagnostic process, being just as specific as the patient’s signs and symptoms.