Hemangioma in the uterine cevix is a rare case, especially during pregnancy. Hemangioma is a benign tumor, but it can cause complication namely antepartum bleeding, preterm labour, and severe, life threatening complication such as disseminated intravascular coagulation (DIC). Histopathology examination is needed to diagnose hemangioma, and to differentiate this disease with other pathological condition. Conservative therapy was chosen as the main option rather than surgical therapy. The case report explain about 2 cases with cervical hemangioma in the uterine in 2 pregnant women. In the case 1 we presented a 27 years old primigravida, 29th weeks gestational age, with antepartum bleeding. A cervical biopsy was done and the histopathological examination reveal a capillary hemangioma within the uterine cervix. The patient was followed up with medications, and a caesarean section was planned to deliver the baby. In the case 2, a 30 years old multigravida with complained of  postpartum bleeding. The clinical manifestation of cervical hemanioma in pregnancy was similar with other pathological condition, such as cervical cancer. A better understanding in pathogenesis and histopathological examination is important to differentiate hemangioma and other pathological condition in uterine cervix. Therapeutic modality was still debated, because of the limitation of literature about hemangioma cervix, especially in pregnant women

Objectives: Severe acute respiratory syndrome-coronavirus 2/COVID-19 infection is still a global concern, with pregnant women are considered as vulnerable population. Until now, the characteristics of pregnant women in Indonesia who are infected with COVID-19, as well as pregnancy and neonatal outcomes, are still unknown. This study aims to obtain national data, which are expected to be useful for the prevention and management of COVID-19 in pregnant women in Indonesia. Methods: There were 1,427 patients recruited in this retrospective multicenter study. This study involved 11 hospitals in 10 provinces in Indonesia and was carried out using secondary patient data from April 2020 to July 2021. COVID-19 severity was differentiated into asymptomatic-to-mild symptoms and moderate-to-severe symptoms. The collected data include maternal characteristics, laboratory examinations, imaging, pregnancy outcomes, and neonatal outcomes. Results: Leukocyte, platelets, basophil, neutrophils segment, lymphocytes, monocytes, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, alanine aminotransferase (ALT), aspartate aminotransferase (AST), C-reactive protein (CRP), urea, and creatinine were found to be significantly associated with severity differences (p < 0.05). Moderate-severe symptoms of COVID-19 also shown to have suggestive pneumonia findings on chest X-ray findings. Patients with asymptomatic-to-mild symptoms had significantly (p < 0.001) higher recovery rate, shorter hospital stay, less intensive care unit (ICU) admission, and had more vaginal delivery. Neonates from mother with mild symptoms also had significantly (p < 0.001) higher survival rate, higher birth weight, and higher APGAR score. Conclusion: Several laboratory and radiology components, as well as maternal and neonatal outcomes are related to the severity of COVID-19 in pregnant women in Indonesia

Purpose: The aim of this study is to evaluate the clinical risk factors associated with maternal death in pregnant women infected by COVID-19. Material and methods: This is a multicenter prospective study in Indonesia, included all pregnant women with confirmed COVID-19. Participants was divided into two groups based on the final outcomes: maternal death group and survived group. The main outcomes evaluated were: maternal background, clinical risk factors, comorbidities, clinical characteristics, and laboratory results. Results: There were 89 participants in the maternal death group and 1673 in survived group. The maternal death group have an older maternal ages (32 vs 31 years old, p=0.03) and earlier gestational ages during admission (33 vs 37 weeks, p=0.000). The maternal death group have a significantly higher rate of cardiac disease (6.5% vs 1.2%, p=0.004), acute kidney injury (5.2% vs 0.3%, p=0.000), coinfections (29.9% vs 10.8%, p=0.000), and anemia (14.3% vs 6.7%, p=0.012). The maternal death group have a higher level of maternal blood leukocyte (13970 vs 10345), netrofil 75.7 vs 70), ALT (47 vs 23), AST (26 vs 19), CRP (37.4 vs 0.7), and procalcitonin (0.27 vs 0.06) (p<0.05). The risk factors that independently related to maternal death are fever (Exp(B): 12.847, 95% CI: 5.638-29.277; p=0.000), pneumonia from chest x-ray (Exp(B): 2.524, 95% CI: 1.163-5.479; p=0.019), and ICU admission (Exp(B): 49.430, 95% CI: 21.024-116.215; p=0.000). Conclussion: Our research indicates that the presence of fever, pneumonia, and ICU hospitalization are independently associated with maternal mortality in COVID-19-infected pregnant women.

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