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Background: The antidiabetic effects of the Pleurotus fossulatus on liver and kidney were unexplored. The present study assessed the vital effects of P. fossulatus aqueous extract (PFA-extract) on liver and kidney function in diabetic rats model. Methods: The albino Wistar rats were divided into five groups with six animals in each. Group, I, II, and III were normal, diabetic, and drug control, respectively, and groups IV and V were test groups. As treatment dose, group II received saline, and group III (drug control) received metformin in 100 mg/kg of body weight as a standard drug. Whereas, group IV (D1) and V (D2) were test groups, received PFA-extract in 250 mg/kg, and 500 mg/kg of body weight, respectively. The changes in body weight, blood glucose level (BGL), lipid profile, liver, and kidney biochemical parameters were evaluated. Results: The PFA-extract dose at 500 mg/kg in D2 groups showed very good effects. The body weight was recovered by 97.9% and blood glucose level (BGL) was reduced to 53% in the D2 group. For the lipid profile, total cholesterol (TC), triglyceride (TG), and high-density lipoprotein (HDL) were estimated in blood plasma and their values were 92.31±3.788, 80.85 ±8.962, and 31.35±1.781, respectively. PFA-extract improved the liver function for which aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were evaluated and recorded to their normal range in D2 group which were 132.01 ±5.553, 58.63±4.390, and 143.26±2.423, respectively. For the kidney function test, creatinine (CRT), blood urea nitrogen (BUN), and uric acid were evaluated and in the D2 group, it was significantly reduced ie, 0.656±0.0707, 15.13±1.463, and 6.27±0.325, respectively. Conclusion: These attributes of PFA-extract make it a potential natural agent to provide protection to the liver and kidney and also reduce the BGL and control the total lipid in type 1 diabetes condition.

The major carp, Labeo rohita fed with six different diets having vitamin C fortification. The Halver's synthetic diet (H440) was supplemented with graded levels of vitamin C at 0, 250, 500, 600, 750 and 1000 mg/kg. In present investigation, Labeo rohita fed with 600 mg/kg vitamin C, gain maximum ash (4.16%), carbohydrate (2.94%) protein (16.87%), fat (5.09 %), SGR (2.92 %), survival rate (100 %) with least moisture content (77.10 %) as compared to control and other graded level of vitamin C. Supplementation of vitamin C beyond 600 mg resulted in decrease in protein, fat, carbohydrate and ash values with an increase in moisture content. The results also indicated that Halver's synthetic diet of fish without dietary vitamin C had lower weight gain (WG) and specific growth rate (SGR) than those fed the diets supplemented vitamin C. WG and SGR did increase with dietary vitamin C levels increasing from 250 mg/ kg to 600 mg / kg. However, no significant increase was observed with further increase in dietary vitamin C levels beyond 600 mg / kg.

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