This study was carried out to assess the infl uence of pharmacist provided patient counseling on patients' perception about the disease management and quality of life in type 2 diabetes mellitus patients. The present study was a randomized, prospective controlled study conducted over a period of six months in two community pharmacies in Calicut, Kerala, India. A total of seventy (48 male and 22 female) type 2 diabetes mellitus patients were enrolled and randomized into test and control groups. Patients in the test group received patient counseling and patient information leafl ets from the pharmacist, where as the control group patients received the counseling and patient information leafl ets only at the end of the study. After the baseline, two follow-ups were made with sixty days interval between the follow-ups. During each visit patient's random capillary blood glucose was measured by using a standard Glucometer. Suitably designed and validated knowledge, attitude and practices questionnaire was administered at baseline and fi nal follow up for both test and control group patients to assess the disease management awareness. Audit of diabetes-dependent quality of life questionnaire was administered to measure the quality of life in both control and test group patients at each follow up. At the end of the study, knowledge, attitude and practices scores found markedly improved in test group patients. Mean capillary blood glucose levels were decreased in test group (P<0.05) and an improvement in mean quality of life scores (P<0.05) was observed. Where as a reduction of quality of life score (P<0.05) and a non-signifi cant increase of capillary blood glucose levels (P>0.05) was observed in the control group patients. The correlation between the capillary blood glucose levels and quality of life scores were also found to be highly signifi cant in the test group (r= 0.955). The results of the study suggests that, pharmacist provided patient counseling has an impact in improving the perception about disease, diet and life style changes and in turn on glycemic control and overall quality of life in diabetic patients. Pharmacist provided patient counseling might be considered as an important element in implementing the disease management program.

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A specific, precise, accurate ultra pressure liquid chromatography (UPLC) method is developed for estimation of chlophedianol hydrochloride in bulk drug and syrup dosage form. The method employed with Hypersil BDS C18 (100 mm x 2.1 mm, 1.7 μm) in a gradient mode, with mobile phase of methanol and acetonitrile in the ratio of 65:35 %v/v. The flow rate was 0.1 ml/min and effluent was monitored at 254 nm. Retention time was found to be 1.130±0.005 min. The method was validated in terms of linearity, accuracy, precision, limit of detection (LOD), limit of quantification (LOQ)in accordance with ICH guidelines. Linear regression analysis data for the calibration plot showed that there was good linear relationship between response and concentration in the range of 20-100 μg/ml respectively. The LOD and LOQ values were found to be 2.094(μg/ml)and 6.3466(μg/ml)respectively. No chromatographic interference from syrup excipients and degradants were found. The proposed method was successfully used for estimation of chlophedianol hydrochloride in syrup dosage form.