Our findings suggest that statins may have therapeutic potential in uveitis. These results need to be confirmed in double-blind, randomized, controlled studies.

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BackgroundStatins have been shown to reduce ocular inflammation in animal models and to prevent development of uveitis in observational studies. There have been no experimental human studies evaluating statins efficacy and safety in uveitis.ObjectivesTo investigate the efficacy and safetyof simvastatin in patients with uveitis associated with HLAB27 and/or rheumatic diseases.MethodsFor this single-center, open-label, randomized study, we enrolled patients with acute uveitis, associated with HLAB27/rheumatic diseases. The patients were randomized to receive 40 mg simvastatin per day for 2 months with the local anti-inflammatorytreatmentor to local anti-inflammatory therapy alone.The studied outcomes were: visual acuity (letters score) conjunctival injection (grades 1-5), and anterior chamber reaction (grades 1-5), the frequency of visual field impairment and posterior synechia. Generalized estimating equations were used to model the relationship between simvastatin use by time interaction and changes in the outcome measures.ResultsForty five patients were enrolled in the study. Twenty two (49%) of them were positive for HLA-B27 without extraocular manifestations, 18 (40%)had concomitant seronegative spondyloarthritis, 4 (9%) had juvenile idiopathic arthritis and 1 (2%) was diagnosed with Behcet's disease. Twenty nine (64%) patients had intermediate uveitis, 13 (29%) anterior uveitis and 3 (7%) panuveitis. Twenty two patients were randomly assigned to receive simvastatinwith local treatment and 23 to local treatment alone. Simvastatin was associated with significant improvement in visual acuity, conjunctival injection and anterior chamber reaction. In patients treated with simvastatin the rates of posterior synechia and visual field impairment were less than in control group (Table).The treatment was well tolerated, only mild side effects were observed.Table 1.Effects of simvastatin on uveitis clinical measuresβ coefficient95% CIP valueVisual acuity (letters score)0,14(0.1 to 0.19)<0.0001Visual field impairment (yes/no)−0,02(−0.06 to 0.03)0.01Conjunctival injection (grades 1–5)−0,09(−0.16 to −0.02)0.01Anterior chamber reaction (grades 1–5)−0,15(−0.3 to 0.0)0.06Posterior synechia (yes/no)−13.5(−15.6 to −11.48)<0.0001ConclusionsOur findings suggest that statins may have therapeutic potential in uveitis. These results should be confirmed in a double blind, randomized, controlled study.Disclosure of InterestNone declared

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