Accumulating clinical and preclinical data indicate a prominent role of gut microbiota in regulation of physiological functions. The gut–brain axis imbalance due to gut dysbiosis is associated with a range of neurodegenerative diseases. Probiotics were suggested not only to restore intestinal dysbiosis but also modulate stress response and improve mood and anxiety symptoms. In this study, we assessed the effects of probiotic lactobacilli on behavioral reactions, the level of oxidative stress and microbiota content in mice administered to broad-spectrum antibiotics. Our study demonstrates that antibiotic treatment of adolescent mice for two weeks resulted in higher mortality and lower weight gain and induced significant changes in behavior including lower locomotor and exploratory activity, reduced muscle strength, visceral hypersensitivity, higher level of anxiety and impaired cognitive functions compared to the control group. These changes were accompanied by decreased diversity and total amount of bacteria, abundance of Proteobacteria and Verrucomicrobia phyla, and reduced Firmicutes/Bacteroides ratio in the gut microbiota. Moreover, a higher level of oxidative stress was found in brain and skeletal muscle tissues of mice treated with antibiotics. Oral administration of two Lactobacillus strains prevented the observed changes and improved not only microbiota content but also the behavioral alterations, suggesting a neuroprotective and antioxidant role of probiotics.

This paper presents the results of an implementation evaluation of a Benefits‐to‐Wages (BtW) program operated in Perm, Russia. In part because of the low level of support for Active Labor Market Programs (ALPs) by Russian national and regional governments, municipalities have begun implementing ALPs of their own. Participation in the BtW program is limited to an unemployed adult in very low income family where at least one child is present. The program appears to be highly successful, with 74% of applicants finding jobs while still participating in the program. The assessment found that participation in the program, and job acquisition in particular, were important in raising participant families' incomes. Nevertheless, only about 10% of participants with jobs were lifted out of poverty. Receipt of certain social services and Employment Services, including training, had little impact on which participants succeeded in finding a job. Similarly, person attributes, such as education and prior work experience paid no statistically significant role. This pattern is consistent with a situation in which job requirements are modest and are met by most program participants. Various patterns indicate the program did have a positive effect on job acquisition, although the absence of a control group prevents any stronger statement.

This article addresses the issue of low targeting efficiency of the Russian child allowance programme. We look at non-take-up of eligible households and inclusion of the noneligible, and show that household characteristics are significant determinants of the programme take-up, as they affect households' earning potential and expected level of benefit. We believe that the results of the research give useful suggestions on how targeting of child allowances can be improved in Russia. Downloaded

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