Authors' contributionWkład autorów: A. Study design/planning zaplanowanie badań B. Data collection/entry zebranie danych C. Data analysis/statistics dane -analiza i statystyki D. Data interpretation interpretacja danych E. Preparation of manuscript przygotowanie artykułu F. Literature analysis/search wyszukiwanie i analiza literatury G. Funds collection zebranie funduszy Summary Background. Female obstetrician-gynecologists of reproductive age provide medical care in harmful working conditions creating health risks for themselves. Material and methods. Female obstetrician-gynecologists working in hospitals (n=32) and antenatal clinics (n=32), therapists of outpatient clinics (n=31) and women working in the positions of accountants, economists, lawyers and secretaries (n=31) in the healthcare organizations of the Grodno region participated in this research. Working conditions were assessed by studying the results of the workplaces' certification. Pre-nosological monitoring was conducted using the following methods: cytomorphological testing of buccal epithelium, microbiological testing of the oral biocenosis and psychological testing. Results. We established that the studied female obstetrician-gynecologists work in harmful conditions (hazard classes 3.2-3.3). It was associated with functional changes in their bodies: 23.3% of them had deviations in cytomorphological parameters of buccal epithelium; 59.3% had excessive amounts of E. coli group bacteria in their oral cavity and already formed phases of the occupational burnout syndrome. Conclusions. The selected set of methods for pre-nosological monitoring permit analysis of the impact of different occupational factors and the formation of target risk groups for the implementation of measures improving adaptive reserves.