Chronic urticaria (CU) is an urgent medical and social problem. The instruments of everyday clinical practice are international and domestic guidelines which briefly reflect modern ideas about various aspects of CU. Recently, a new opportunity has emerged to expand theoretical and practical experience in the management of patients with CU, to carry out educational activities to disseminate modern knowledge about urticaria, to conduct research in the field of studying the pathogenesis, treatment, and prevention of exacerbations of the disease. This opportunity is realized through the centers of excellence for working with such patients (GALEN UCARE centers). One of the five Russian centers, have prepared and conducted an online training program "Chronic urticaria: scientific and medical achievements and practical aspects of patient management." at the Federal State Budgetary Institution State Research Center "Institute of Immunology" FMBA of Russia. The event was held by the employees of the Federal State Budgetary Institution State Research Center "Institute of Immunology" of the FMBA of Russia on November , 2020.

Objective: To assess the possibility of using a drug solution of Acarizax containing Derm house dust allergens. pteronyssinus and Derm. farinae in equal amounts - 12 SQ-HDM, in order to conduct skin prick tests to confirm the sensitization of patients to ODP.Methods: Skin prick tests with dilutions 1 tablet per 2.5 and 5 ml diluting liquid of the study drug with positive and negative controls. Statistical data processing was carried out using the Statistica 13.3 or IBM SPSS 17.0 software package. To analyze efficacy and safety data, standard parametric tests were used: Student's t-test for dependent/independent samples, analysis of variance (ANOVA) for repeated measurements, Mann-Whitney U-test, Shapiro-Wilk test. The analysis of AEs was planned to be based on an estimate of the frequency of AEs/serious AEs.Results: The correlation between the total level of specific IgE to tick allergens Derm was assessed. pteronyssinus and Derm. farinae measured at screening and papule size 20 minutes after application of the drug at a dilution of 1 tablet per 2.5 ml and 5 ml of diluting liquid - the correlation coefficient (r) in both groups (general) was 0.735 (high correlation), and 0.762 (high correlation) respectively. The result is statistically significant (p0.05) in both groups. A clinical trial has shown that the drug Acarizax, containing house dust allergens Derm. pteronyssinus and Derm.s farinae in equal amounts - 12 SQ-HDM, when used for the purpose of skin prick tests to confirm the sensitization of patients to ODP, is a safe and informative method.Conclusions: In order to conduct skin prick tests to confirm the sensitization of patients to ODP, the study drug can be used in a larger dilution - 1 tablet per 5 ml of diluting liquid. Acarizax medicinal product containing house dust allergens Derm. pteronyssinus and Derm. farinae in equal amounts - 12 SQ-HDM, when used for skin prick tests, is informative and well tolerated by patients.