Objective: To obtain the effectiveness of propolis fluoride application in inhibiting dental caries activity. Methods:The study was included 170 children aged 6-9 years old with active dentinal carries surface was 532 tooth surfaces, all of 532 tooth surface will applicate use propolis fluoride in school children at primary school SD Kukusan. Evaluation of the amount of dentinal caries lesion that has been arrested was conducted after 1 month, 2 months, and 4 months after topical application. Results:After propolis fluoride applicated shows, that the activated process caries of dentinal caries lesion after 1 month was found in 104 tooth surfaces, 2 months were 115 tooth surfaces, and after 4 months evaluated were found significant increase to be 226 tooth surfaces on dentinal caries activated from 2 nd to 4 th month after application propolis fluoride (p<0.01). The percentages of arrested caries in, respectively, for 1 st month after the application is 99.80%, 2 nd month application is 78.32%, and in the 4 th month is 57.52% while the score plaque of school children was decline significantly until 36.5% (p<0.05) after 4 months intervention by tooth brushing every week at school. Conclusion:The application of propolis fluoride is effective in inhibiting dentinal caries lesion activity, has the advantage of making no black discoloration to the teeth.